VEGF Receptor 3 antibody | 5B5

Mouse anti Human VEGF Receptor 3:Preservative Free

Product Type
Monoclonal Antibody
Clone
5B5
Isotype
IgG2a
Specificity
VEGF Receptor 3

Product Code Applications Pack Size List Price Your Price Qty
MCA5331Z
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 0.1 mg loader
List Price Your Price
loader
Search for Batch Specific Datasheets

Mouse anti Human VEGF receptor 3 antibody, clone 5B5 recognizes human vascular endothelial growth factor receptor 3, also known as Fms-like tyrosine kinase 4, FLT-4 or Tyrosine-protein kinase receptor FLT4. FLT-4 is a 1339 amino acid ~160 kDa single pass type 1 transmembrane glycoprotein receptor for VEGFC and VEGFD, playing an essential role in adult lymphangiogenesis.

Three isoforms produced by alternative splicing have been described. Mouse anti Human VEGF receptor 3 antibody, clone 5B5 binds to the canonical isoform 1, isoforms 2 and 3 also preserve the complete unaltered immunogen sequence used to generate clone 5B5 and therefore also be expected to be recognized by the antibody.

Mutations of the FLT4 gene can lead to Lymphedema, hereditary, 1A (LMPH1A), a chronic condition with swelling of the extremities caused by alterations in lymph flow (Irrthum et al. 2000). Mutations can also lead to increases susceptibility to Hemangioma, capillary infantile (HCI), a condition characterised by sharply demarcated skin hemangiomas present at birth or within the first few months after birth as a result of highly proliferative capillary endothelial growth. These generally undergo regression and involution (Walter et al. 2002).

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
None present
Immunogen
Recombinant protein corresponding to aa 34-133 of human VEGF receptor 3.
Approx. Protein Concentrations
Ig concentration 0.5 mg/ml
Fusion Partners
Spleen cells from BALB/c mice were fused with cells from the Sp2/0 myeloma cell line.
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 0.1 10 ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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RRID
AB_2105121
UniProt
P35916
Entrez Gene
FLT4
GO Terms
GO:0005515 protein binding
GO:0005021 vascular endothelial growth factor receptor activity
GO:0005887 integral to plasma membrane
GO:0005524 ATP binding
GO:0006468 protein phosphorylation
GO:0008284 positive regulation of cell proliferation
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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