Unconventional Myosin 6 antibody | CD02/3A9

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Anti Unconventional Myosin 6 Antibody, clone CD02/3A9 (PrecisionAb Monoclonal Antibody) thumbnail image 1

Anti Unconventional Myosin 6 Antibody, clone CD02/3A9 (PrecisionAb Monoclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with unconventional myosin 6 antibody (1/500, **VMA00807**) followed by detection with HRP conjugated Goat anti Mouse IgG (1/10,000, STAR207P) and visualized on the ChemiDoc MP. Arrows points to unconventional myosin 6 (molecular weight 140 kDa)

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Mouse anti Unconventional Myosin 6

Product Type: PrecisionAb Monoclonal
Clone: CD02/3A9
Isotype: IgG1
Format: Purified
Specificity: Unconventional Myosin 6

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VMA00807 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Mouse anti Unconventional Myosin 6 antibody recognizes unconventional myosin-6 (MYO6).

Unconventional Myosin 6 is an actin-based motor protein which moves cargo towards the minus end of actin filaments, in the opposite direction to every other myosin. Due to its unique function, and its role in a wide variety of cellular processes including endocytosis, polarized secretion, and autophagy (Masters et al. 2017). Unconventional Myosin 6 upregulation is a hallmark of various cancer types, is critical for maintaining malignant properties, and contributes to tumor cell migration and metastasis (Lei et al. 2017). The loss or overexpression of Unconventional Myosin 6 is also associated with neurodegenerative diseases, cardiomyopathy, deafness, and other pathologies (de Jonge et al. 2019).

Target Species: Human
Western Blotting: Mouse anti unconventional myosin 6 antibody detects a band of approximately 140 kDa in MCF-7 cell lysates
Product Form: Purified IgG - Liquid
Preparation: Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution: Phosphate buffered saline
Preservative Stabilisers: 0.09% Sodium Azide
Immunogen: E. coli-derived recombinant protein of amino acids 1042-1294 of human MYO6
Approx. Protein Concentrations: IgG concentration 1.0 mg/ml
Fusion Partners: Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Regulatory: For research purposes only
Guarantee: 12 months from date of despatch
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/500	1/2000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Mouse IgG (H/L):HRP	STAR207P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Mouse IgG (H/L):HRP

UniProt: Q9UM54
Entrez Gene: MYO6
GO Terms: GO:0005515 protein binding; GO:0051015 actin filament binding; GO:0005829 cytosol; GO:0005516 calmodulin binding; GO:0005524 ATP binding; GO:0005794 Golgi apparatus; GO:0005905 coated pit; GO:0005938 cell cortex; GO:0006897 endocytosis; View More GO Terms; GO:0007268 synaptic transmission; GO:0007605 sensory perception of sound; GO:0030048 actin filament-based movement; GO:0016461 unconventional myosin complex; GO:0016591 DNA-directed RNA polymerase II, holoenzyme; GO:0030330 DNA damage response, signal transduction by p53 class mediator; GO:0030665 clathrin coated vesicle membrane; GO:0031941 filamentous actin; GO:0031965 nuclear membrane; GO:0032587 ruffle membrane; GO:0043531 ADP binding; GO:0045944 positive regulation of transcription from RNA polymerase II promoter; GO:0048471 perinuclear region of cytoplasm; GO:0051046 regulation of secretion; GO:0060001 minus-end directed microfilament motor activity