Unconventional Myosin 6 antibody | CD02/3A9

Mouse anti Unconventional Myosin 6

Product Type
PrecisionAb Monoclonal
Clone
CD02/3A9
Isotype
IgG1
Format
Purified
Specificity
Unconventional Myosin 6

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VMA00807
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Mouse anti Unconventional Myosin 6 antibody recognizes unconventional myosin-6 (MYO6).

Unconventional Myosin 6 is an actin-based motor protein which moves cargo towards the minus end of actin filaments, in the opposite direction to every other myosin. Due to its unique function, and its role in a wide variety of cellular processes including endocytosis, polarized secretion, and autophagy (Masters et al. 2017). Unconventional Myosin 6 upregulation is a hallmark of various cancer types, is critical for maintaining malignant properties, and contributes to tumor cell migration and metastasis (Lei et al. 2017). The loss or overexpression of Unconventional Myosin 6 is also associated with neurodegenerative diseases, cardiomyopathy, deafness, and other pathologies (de Jonge et al. 2019).
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Mouse anti unconventional myosin 6 antibody detects a band of approximately 140 kDa in MCF-7 cell lysates
Product Form
Purified IgG - Liquid
Preparation
Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
Immunogen
E. coli-derived recombinant protein of amino acids 1042-1294 of human MYO6
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/500 1/2000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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UniProt
Q9UM54
Entrez Gene
MYO6
GO Terms
GO:0005515 protein binding
GO:0051015 actin filament binding
GO:0005829 cytosol
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005794 Golgi apparatus
GO:0005905 coated pit
GO:0005938 cell cortex
GO:0006897 endocytosis
GO:0007268 synaptic transmission
GO:0007605 sensory perception of sound
GO:0030048 actin filament-based movement
GO:0016461 unconventional myosin complex
GO:0016591 DNA-directed RNA polymerase II, holoenzyme
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0030665 clathrin coated vesicle membrane
GO:0031941 filamentous actin
GO:0031965 nuclear membrane
GO:0032587 ruffle membrane
GO:0043531 ADP binding
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048471 perinuclear region of cytoplasm
GO:0051046 regulation of secretion
GO:0060001 minus-end directed microfilament motor activity
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