Unconventional Myosin 6 antibody | CD02/3A9
Mouse anti Unconventional Myosin 6 antibody recognizes unconventional myosin-6 (MYO6).
Unconventional Myosin 6 is an actin-based motor protein which moves cargo towards the minus end of actin filaments, in the opposite direction to every other myosin. Due to its unique function, and its role in a wide variety of cellular processes including endocytosis, polarized secretion, and autophagy (Masters et al. 2017). Unconventional Myosin 6 upregulation is a hallmark of various cancer types, is critical for maintaining malignant properties, and contributes to tumor cell migration and metastasis (Lei et al. 2017). The loss or overexpression of Unconventional Myosin 6 is also associated with neurodegenerative diseases, cardiomyopathy, deafness, and other pathologies (de Jonge et al. 2019).
Unconventional Myosin 6 is an actin-based motor protein which moves cargo towards the minus end of actin filaments, in the opposite direction to every other myosin. Due to its unique function, and its role in a wide variety of cellular processes including endocytosis, polarized secretion, and autophagy (Masters et al. 2017). Unconventional Myosin 6 upregulation is a hallmark of various cancer types, is critical for maintaining malignant properties, and contributes to tumor cell migration and metastasis (Lei et al. 2017). The loss or overexpression of Unconventional Myosin 6 is also associated with neurodegenerative diseases, cardiomyopathy, deafness, and other pathologies (de Jonge et al. 2019).
Product Details
- Target Species
- Human
- Western Blotting
- Mouse anti unconventional myosin 6 antibody detects a band of approximately 140 kDa in MCF-7 cell lysates
- Product Form
- Purified IgG - Liquid
- Preparation
- Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- Immunogen
- E. coli-derived recombinant protein of amino acids 1042-1294 of human MYO6
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Storage Information
- Storage
- Store undiluted at -20°C, avoiding repeated freeze thaw cycles
- Guarantee
- 12 months from date of despatch
More Information
- UniProt
- Q9UM54
- Entrez Gene
- MYO6
- GO Terms
- GO:0005515 protein binding
- GO:0051015 actin filament binding
- GO:0005829 cytosol
- GO:0005516 calmodulin binding
- GO:0005524 ATP binding
- GO:0005794 Golgi apparatus
- GO:0005905 coated pit
- GO:0005938 cell cortex
- GO:0006897 endocytosis
- GO:0007268 synaptic transmission
- GO:0007605 sensory perception of sound
- GO:0030048 actin filament-based movement
- GO:0016461 unconventional myosin complex
- GO:0016591 DNA-directed RNA polymerase II, holoenzyme
- GO:0030330 DNA damage response, signal transduction by p53 class mediator
- GO:0030665 clathrin coated vesicle membrane
- GO:0031941 filamentous actin
- GO:0031965 nuclear membrane
- GO:0032587 ruffle membrane
- GO:0043531 ADP binding
- GO:0045944 positive regulation of transcription from RNA polymerase II promoter
- GO:0048471 perinuclear region of cytoplasm
- GO:0051046 regulation of secretion
- GO:0060001 minus-end directed microfilament motor activity
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
- Regulatory
- For research purposes only
Applications of Unconventional Myosin 6 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/500 | 1/2000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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