UBE2D2 antibody | OTI3H1

Mouse anti UBE2D2

Product Type
PrecisionAb Monoclonal
Clone
OTI3H1
Isotype
IgG2b
Format
Purified
Specificity
UBE2D2

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VMA00492
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 100 µl loader
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Mouse anti Human UBE2D2 antibody recognizes the ubiquitin-conjugating enzyme E2 D2, also known as p53-regulated ubiquitin-conjugating enzyme 1, ubiquitin carrier protein D2, ubiquitin-conjugating enzyme E2 D2 or ubiquitin-protein ligase D2.

Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. UBE2D2 gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of UBE2D2 (provided by RefSeq, May 2013).

Mouse anti Human UBE2D2 antibody detects a band of 17 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti UBE2D2 detects a band of approximately 17 kDa in HEK293 cell lysate.
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G from ascites.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
50% Glycerol
Immunogen
Full length human recombinant protein of human UBE2D2 produced in E. Coli.
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml loader
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Description Goat anti Mouse IgG (H/L):HRP

UniProt
P62837
Entrez Gene
UBE2D2
GO Terms
GO:0005515 protein binding
GO:0004842 ubiquitin-protein ligase activity
GO:0005524 ATP binding
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0043687 post-translational protein modification
GO:0051246 regulation of protein metabolic process
GO:0070936 protein K48-linked ubiquitination
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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