TTF1 antibody | RM373
Rabbit anti TTF1
- Product Type
- Monoclonal Antibody
- Clone
- RM373
- Isotype
- IgG
- Specificity
- TTF1
Antibody Quality and Performance Guarantee
| Rabbit anti TTF1 antibody recognizes homeobox protein Nkx-2.1, also known as NKX2-1 and thyroid transcription factor 1 (TTF1). TTF1 is a homeobox-containing transcription factor expressed during embryonic development of the thyroid, respiratory epithelium, and diencephalon. Expression of TTF1 in normal tissues is restricted to the thyroid and pulmonary epithelium, but the gene can be overexpressed in thyroid tumors and pulmonary neoplasms (Aversa and Bellan 2018). As such, TTF1 is used alongside GATA3 to distinguish primary lung adenocarcinoma from metastatic bladder cancer (Zhao et al. 2019). TTF1 appears to have dual roles in cancer cell survival and progression (Huang et al. 2017). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol - Immunogen
- A peptide corresponding to the N-terminus of human TTF1
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin |  |
1/500 | 1/1000 |
| Western Blotting | |
1/1000 | 1/2000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E WB | 1 mg |
|
Log in | ||
| List Price | Your Price | ||||||
|
|
Log in | ||||||
| Description | Goat anti Rabbit IgG (Fc):Biotin | ||||||
| Goat anti Rabbit IgG (Fc):FITC | STAR121F | F | 1 mg |
|
Log in | ||
| List Price | Your Price | ||||||
|
|
Log in | ||||||
| Description | Goat anti Rabbit IgG (Fc):FITC | ||||||
| Goat anti Rabbit IgG (Fc):HRP | STAR121P | E WB | 1 mg |
|
Log in | ||
| List Price | Your Price | ||||||
|
|
Log in | ||||||
| Description | Goat anti Rabbit IgG (Fc):HRP | ||||||
| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C E WB | 1 mg |
|
Log in | ||
| List Price | Your Price | ||||||
|
|
Log in | ||||||
| Description | Goat anti Rabbit IgG (H/L):HRP | ||||||
| Sheep anti Rabbit IgG:RPE | STAR35A | F | 1 ml |
|
Log in | ||
| List Price | Your Price | ||||||
|
|
Log in | ||||||
| Description | Sheep anti Rabbit IgG:RPE | ||||||
- UniProt
- P43699
- Entrez Gene
- NKX2-1
- GO Terms
- GO:0005515 protein binding
- GO:0009725 response to hormone stimulus
- GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0010719 negative regulation of epithelial to mesenchymal transition
- GO:0010843 promoter binding
- GO:0016563 transcription activator activity
- GO:0021759 globus pallidus development
- GO:0030336 negative regulation of cell migration
- GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
- View More GO Terms
- GO:0030878 thyroid gland development
- GO:0060441 epithelial tube branching involved in lung morphogenesis
MCA6354
157617
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
Request a different product with this specificity
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
View all Anti-Human ProductsAlways be the first to know.
When we launch new products and resources to help you achieve more in the lab.
Yes, sign me up