Rabbit anti TTF1 antibody
recognizes homeobox protein Nkx-2.1, also known as NKX2-1 and thyroid transcription factor 1 (TTF1).
TTF1 is a homeobox-containing transcription factor expressed during embryonic development of the thyroid, respiratory epithelium, and diencephalon. Expression of TTF1 in normal tissues is restricted to the thyroid and pulmonary epithelium, but the gene can be overexpressed in thyroid tumors and pulmonary neoplasms (Aversa and Bellan 2018
). As such, TTF1 is used alongside GATA3 to distinguish primary lung adenocarcinoma from metastatic bladder cancer (Zhao et al. 2019
). TTF1 appears to have dual roles in cancer cell survival and progression (Huang et al. 2017
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
- A peptide corresponding to the N-terminus of human TTF1
- Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
response to hormone stimulus
positive regulation of gene-specific transcription from RNA polymerase II promoter
negative regulation of epithelial to mesenchymal transition
transcription activator activity
globus pallidus development
negative regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
thyroid gland development
epithelial tube branching involved in lung morphogenesis
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of TTF1 antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
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