TTF1 antibody | RM373

Rabbit anti TTF1

Product Type
Monoclonal Antibody
Clone
RM373
Isotype
IgG
Specificity
TTF1

Product Code Applications Pack Size List Price Your Price Qty
MCA6354
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SDS Safety Datasheet SDS
P WB 0.1 ml loader
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Rabbit anti TTF1 antibody recognizes homeobox protein Nkx-2.1, also known as NKX2-1 and thyroid transcription factor 1 (TTF1).

TTF1 is a homeobox-containing transcription factor expressed during embryonic development of the thyroid, respiratory epithelium, and diencephalon. Expression of TTF1 in normal tissues is restricted to the thyroid and pulmonary epithelium, but the gene can be overexpressed in thyroid tumors and pulmonary neoplasms (Aversa and Bellan 2018). As such, TTF1 is used alongside GATA3 to distinguish primary lung adenocarcinoma from metastatic bladder cancer (Zhao et al. 2019). TTF1 appears to have dual roles in cancer cell survival and progression (Huang et al. 2017).

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
1% Bovine Serum Albumin
50% Glycerol
Immunogen
A peptide corresponding to the N-terminus of human TTF1
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1/500 1/1000
Western Blotting 1/1000 1/2000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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UniProt
P43699
Entrez Gene
NKX2-1
GO Terms
GO:0005515 protein binding
GO:0009725 response to hormone stimulus
GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0010843 promoter binding
GO:0016563 transcription activator activity
GO:0021759 globus pallidus development
GO:0030336 negative regulation of cell migration
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030878 thyroid gland development
GO:0060441 epithelial tube branching involved in lung morphogenesis
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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