Troponin I (Cardiac) antibody

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Mouse anti Troponin I (Cardiac)

Product Type: PrecisionAb Monoclonal
Isotype: IgG2a
Format: Purified

Product Code	Applications	Pack Size	Your Price	List Price	Quantity
VMA00419 Datasheet	WB MSDS	100 µl	Log in		Get Quote

Summary
Secondary Antibodies

Mouse anti Human troponin I (cardiac) antibody recognizes the troponin I (TnI) protein expressed in the heart tissue also known as troponin I type 3 (cardiac). Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. Encoded by the TNN13 gene, TnI-cardiac is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM) (provided by RefSeq, Jul 2008).

Mouse anti Human troponin I (cardiac) antibody detects a band of 24 kDa. The antibody has been validated for western blotting using human heart lysate.

Product Details

Target Species: Human
Western Blotting: Anti troponin (cardiac) detects a band of approximately 24 kDa in human heart tissue
Product Form: Purified IgG - liquid
Preparation: Mouse monoclonal antibody purified by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution: Phosphate buffered saline
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃)
Immunogen: Native troponin I protein purified from human cardiac tissue

Storage Information

Storage: Store undiluted at -20^oC, avoiding repeated freeze thaw cycles.
Guarantee: As supplied, 12 months from date of despatch.

More Information

UniProt: P19429
Entrez Gene: TNNI3
GO Terms: GO:0001570 vasculogenesis; GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions; GO:0003779 actin binding; GO:0005829 cytosol; GO:0005861 troponin complex; GO:0006874 cellular calcium ion homeostasis; GO:0019855 calcium channel inhibitor activity; GO:0019901 protein kinase binding; GO:0019904 protein domain specific binding; GO:0030049 muscle filament sliding; GO:0030172 troponin C binding; GO:0031014 troponin T binding; GO:0032780 negative regulation of ATPase activity; GO:0048306 calcium-dependent protein binding; GO:0055010 ventricular cardiac muscle tissue morphogenesis; GO:0060048 cardiac muscle contraction
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.
Regulatory: For research purposes only

Applications of Troponin I (Cardiac) antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description	Product Code	Applications	Pack Size	Your Price	List Price	Quantity
Goat anti Mouse IgG (H/L):HRP	STAR207P	WB	2 ml	Log in		Get Quote

A Precise Solution to Reproducible Western Blots - PrecisionAb Antibodies

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