Troponin I (Cardiac) antibody

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Anti Troponin I (Cardiac) Antibody (PrecisionAb Monoclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with Mouse anti Human troponin I (cardiac) antibody (**VMA00419**) followed by detection with HRP conjugated Goat anti Mouse IgG (1/50,000, STAR207P) and visualized on the ChemicDoc MP with 11 second exposure. Arrow points to troponin I (cardiac) (molecular weight 24 kDa).

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Mouse anti Troponin I (Cardiac)

Product Type: PrecisionAb Monoclonal
Isotype: IgG2a
Format: Purified
Specificity: Troponin I (Cardiac)

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VMA00419 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Mouse anti Human troponin I (cardiac) antibody recognizes the troponin I (TnI) protein expressed in the heart tissue also known as troponin I type 3 (cardiac). Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. Encoded by the TNN13 gene, TnI-cardiac is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM) (provided by RefSeq, Jul 2008).

Mouse anti Human troponin I (cardiac) antibody detects a band of 24 kDa. The antibody has been validated for western blotting using human heart lysate.

Target Species: Human
Western Blotting: Anti troponin (cardiac) detects a band of approximately 24 kDa in human heart tissue.
Product Form: Purified IgG - liquid
Preparation: Mouse monoclonal antibody purified by affinity chromatography on Protein G from tissue culture supernatant.
Buffer Solution: Phosphate buffered saline.
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃).
Immunogen: Native troponin I protein purified from human cardiac tissue
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch.
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Mouse IgG (H/L):HRP	STAR207P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Mouse IgG (H/L):HRP

UniProt: P19429
Entrez Gene: TNNI3
GO Terms: GO:0001570 vasculogenesis; GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions; GO:0003779 actin binding; GO:0005829 cytosol; GO:0005861 troponin complex; GO:0006874 cellular calcium ion homeostasis; GO:0019855 calcium channel inhibitor activity; GO:0019901 protein kinase binding; GO:0019904 protein domain specific binding; View More GO Terms; GO:0030049 muscle filament sliding; GO:0030172 troponin C binding; GO:0031014 troponin T binding; GO:0032780 negative regulation of ATPase activity; GO:0048306 calcium-dependent protein binding; GO:0055010 ventricular cardiac muscle tissue morphogenesis; GO:0060048 cardiac muscle contraction