TRIM24 antibody | OTI2D9

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Anti TRIM24 Antibody, clone OTI2D9 (PrecisionAb Monoclonal Antibody) thumbnail image 1

Anti TRIM24 Antibody, clone OTI2D9 (PrecisionAb Monoclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with TRIM24 antibody followed by detection with HRP conjugated Goat anti Mouse IgG (1/10,000, STAR207P) and visualized on the ChemiDoc MP with 18 second exposure. Arrow points to TRIM24 (molecular weight 130 kDa)

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Mouse anti TRIM24

Product Type: PrecisionAb Monoclonal
Clone: OTI2D9
Isotype: IgG1
Format: Purified
Specificity: TRIM24

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VMA00396 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Mouse anti Human TRIM24 antibody, clone OTI2D9 recognizes E3 ubiquitin-protein ligase TRIM24, also known as RING finger protein 82, TIF1-alpha, transcriptional intermediary factor 1 and tripartite motif-containing 24.

Encoded by the TRIM24 gene, E3 ubiquitin-protein ligase TRIM24 mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for TRIM24 (provided by RefSeq, Jul 2008).

Mouse anti Human TRIM24 antibody, clone OTI2D9 detects a band of 130 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Target Species: Human
Western Blotting: Anti TRIM24 detects a band of approximately 130 kDa in HepG2 cell lysates.
Product Form: Purified IgG - liquid.
Preparation: Mouse monoclonal antibody purified by affinity chromatography from ascites.
Buffer Solution: Phosphate buffered saline.
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃)
1% Bovine Serum Albumin
50% Glycerol
Immunogen: Recombinant protein fragment corresponding to aa 706-1016 of human TRIM24 (NP_003843) produced in E.coli
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch.
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Mouse IgG (H/L):HRP	STAR207P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Mouse IgG (H/L):HRP

UniProt: O15164
Entrez Gene: TRIM24
GO Terms: GO:0002039 p53 binding; GO:0003682 chromatin binding; GO:0003713 transcription coactivator activity; GO:0004842 ubiquitin-protein ligase activity; GO:0006366 transcription from RNA polymerase II promoter; GO:0008270 zinc ion binding; GO:0042981 regulation of apoptosis; GO:0030163 protein catabolic process; GO:0031647 regulation of protein stability; View More GO Terms; GO:0034056 estrogen response element binding; GO:0070577 histone acetyl-lysine binding; GO:0071391 cellular response to estrogen stimulus