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TMS1 antibody | OTI1A2

Mouse anti TMS1

Product Type
PrecisionAb Monoclonal
Clone
OTI1A2
Isotype
IgG1
Format
Purified
Specificity
TMS1

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VMA00183
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 100 µl loader
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Mouse anti Human TMS1 antibody, clone OTI1A2 recognizes target of methylation-induced silencing 1 (TMS1), also known as apoptosis-associated speck-like protein containing a CARD and caspase recruitment domain-containing protein 5.

The TMS1 (PYCARD) gene encodes TMS1, an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for PYCARD (provided by RefSeq, Jul 2008).

Mouse anti Human TMS1 antibody, clone OTI1A2 detects a band of 22 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti TMS1 detects a band of approximately 22 kDa in THP-1 cell lysates.
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody purified by affinity chromatography from ascites.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
50% Glycerol
Immunogen
Full length recombinant human TMS1 protein produced in E. coli
Approx. Protein Concentrations
IgG concentration 0.5 mg/ml.
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml loader
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Description Goat anti Mouse IgG (H/L):HRP

UniProt
Q9ULZ3
Entrez Gene
PYCARD
GO Terms
GO:0004197 cysteine-type endopeptidase activity
GO:0006508 proteolysis
GO:0006917 induction of apoptosis
GO:0006919 activation of caspase activity
GO:0008385 IkappaB kinase complex
GO:0008656 caspase activator activity
GO:0032090 Pyrin domain binding
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042803 protein homodimerization activity
GO:0050718 positive regulation of interleukin-1 beta secretion
GO:0051092 positive regulation of NF-kappaB transcription factor activity

VMA00183

240615

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