TMEM173 antibody | 4H1

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Mouse anti TMEM173

Mouse anti-human TMEM173 antibody recognizes the stimulator of interferon genes protein, also known as N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner, or endoplasmic reticulum interferon stimulator.

Product Type
PrecisionAb™ Monoclonal
Clone
4H1
Isotype
IgG2a
Format
Purified
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
VMA00456 WB 100 µl
Mouse anti Human TMEM173 antibody recognizes TMEM173, also known as N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner, endoplasmic reticulum interferon stimulator, mitochondrial mediator of IRF3 activation or STING. Mutationsin the TMEM173 gene have been associated with the development of STING-associated vasculopathy with onset in infancy (SAVI) an autoinflammatory vasculopathy characterized by early onset inflammation leading to severe skin associated lesions.

Mouse anti Human TMEM173 antibody detects a band of 37 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Product Details

Target Species
Human
Western Blotting
Anti TMEM173 detects a band of approximately 37 kDa in THP-1 cell lysate
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G from ascites
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
50% Glycerol
Immunogen
Full length recombinant protein of human TMEM173 produced in HEK293T
Instructions For Use
Please refer to the PrecisionAb western blotting protocol. For additional information on secondary antibody dilution and exposure time see product web page.

Storage Information

Storage
Store undiluted at -20oC, avoiding repeated freeze thaw cycles.
Shelf Life
As supplied, 12 months from date of despatch.

More Information

UniProt
Q86WV6 Related reagents
Entrez Gene
TMEM173 Related reagents
GO Terms
GO:0005886 plasma membrane
GO:0006915 apoptosis
GO:0016021 integral to membrane
GO:0005741 mitochondrial outer membrane
GO:0005789 endoplasmic reticulum membrane
GO:0019901 protein kinase binding
GO:0032608 interferon-beta production
GO:0042803 protein homodimerization activity
GO:0045087 innate immune response
GO:0048471 perinuclear region of cytoplasm
GO:0051607 defense response to virus
Acknowledgements
PrecisionAbâ„¢ is a trademark of Bio-Rad Laboratories.
Regulatory
For research purposes only

Applications of TMEM173 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

PrecisionAb antibodies have been extensively validated for the western blot application. The antibody has been validated at the suggested dilution. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependant on sample type.

Secondary Antibodies Available

Description Product Code Pack Size Applications List Price Quantity
Goat anti Mouse IgG (H/L):HRP STAR207P 2 ml WB

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