Tissue Factor Pathway Inhibitor antibody | OTI4H9
Mouse anti Human tissue factor pathway inhibitor antibody, clone OTI4H9 recognizes tissue factor pathway inhibitor, also known as anti-convertin and extrinsic pathway inhibitor.
Encoded by the TFPI gene, tissue factor pathway inhibitor is a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of TFPI inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of TFPI have been described, but the full-length nature of some of these variants has not been confirmed (provided by RefSeq, Jul 2008).
Mouse anti Human tissue factor pathway inhibitor antibody, clone OTI4H9 detects a band of 40-45 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Encoded by the TFPI gene, tissue factor pathway inhibitor is a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of TFPI inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of TFPI have been described, but the full-length nature of some of these variants has not been confirmed (provided by RefSeq, Jul 2008).
Mouse anti Human tissue factor pathway inhibitor antibody, clone OTI4H9 detects a band of 40-45 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Product Details
- Target Species
- Human
- Western Blotting
- Anti tissue factor pathway inhibitor detects a band of approximately 40-45 kDa in HepG2 cell lysates
- Product Form
- Purified IgG - liquid
- Preparation
- Mouse monoclonal antibody purified by affinity chromatography from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
50% Glycerol - Immunogen
- Recombinant protein corresponding to amino acids 29-304 of human tissue factor pathway inhibitor (NP_006278) produced in E. coli
Storage Information
- Storage
- Store undiluted at -20oC, avoiding repeated freeze thaw cycles.
- Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P10646
- Entrez Gene
- TFPI
- GO Terms
- GO:0005886 plasma membrane
- GO:0004867 serine-type endopeptidase inhibitor activity
- GO:0005615 extracellular space
- GO:0007598 blood coagulation, extrinsic pathway
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories.
- Regulatory
- For research purposes only
Applications of Tissue Factor Pathway Inhibitor antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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