Tissue Factor Pathway Inhibitor antibody | OTI4H9

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Mouse anti Tissue Factor Pathway Inhibitor

Product Type
PrecisionAb Monoclonal
Clone
OTI4H9
Isotype
IgG2a
Format
Purified
Product Code Applications Pack Size List Price Quantity
VMA00293
Datasheet
WB
MSDS
100 µl loader

Mouse anti Human tissue factor pathway inhibitor antibody recognizes tissue factor pathway inhibitor, also known as anti-convertin and extrinsic pathway inhibitor.

Encoded by the TFPI gene, tissue factor pathway inhibitor is a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of TFPI inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of TFPI have been described, but the full-length nature of some of these variants has not been confirmed (provided by RefSeq, Jul 2008).

Mouse anti Human tissue factor pathway inhibitor antibody detects a band of 40-45 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Product Details

Target Species
Human
Western Blotting
Anti tissue factor pathway inhibitor detects a band of approximately 40-45 kDa in HepG2 cell lysates
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody purified by affinity chromatography from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
50% Glycerol
Immunogen
Recombinant protein corresponding to amino acids 29-304 of human tissue factor pathway inhibitor (NP_006278) produced in E. coli

Storage Information

Storage
Store undiluted at -20oC, avoiding repeated freeze thaw cycles.
Guarantee
As supplied, 12 months from date of despatch.

More Information

UniProt
P10646 Related reagents
Entrez Gene
TFPI Related reagents
GO Terms
GO:0005886 plasma membrane
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005615 extracellular space
GO:0007598 blood coagulation, extrinsic pathway
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.
Regulatory
For research purposes only

Applications of Tissue Factor Pathway Inhibitor antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml

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