Thymidylate Synthase antibody | TS106
No associated image currently available
Mouse anti Human Thymidylate Synthase
- Product Type
- Monoclonal Antibody
- Clone
- TS106
- Isotype
- IgG1
- Specificity
- Thymidylate Synthase
Antibody Quality and Performance Guarantee
| Mouse anti Human thymidylate synthase antibody, clone TS106 recognizes thymidylate synthase, an enzyme that is essential for DNA biosynthesis and acts by converting dUMP to dTMP. Thymidylate synthase is a target for the fluoropyrimidine group of cytotoxic drugs that are used to treat solid tumours. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.1% Sodium Azide (NaN3)
- Immunogen
- Recombinant thymidylate synthase.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
||
| Flow Cytometry | |
||
| Immunofluorescence | |
||
| Immunohistology - Frozen | |
1/50 | 1/100 |
| Immunohistology - Paraffin | |
1/50 | 1/100 |
| Immunoprecipitation | |
||
| Western Blotting | |
1/200 | 1/400 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- OBT1127 detects a band of approximately 36 kDa under reduced conditions.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse IgG1 Negative Control | MCA928 | F | 100 Tests |
|
Log in | ||
| List Price | Your Price | ||||||
|
|
Log in | ||||||
| Description | Mouse IgG1 Negative Control | ||||||
References for Thymidylate Synthase antibody
-
Johnston, P.G. et al. (1991) Production and characterization of monoclonal antibodies that localize human thymidylate synthase in the cytoplasm of human cells and tissue.
Cancer Res. 51 (24): 6668-76. -
Johnston, P.G. et al. (1992) Immunological quantitation of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil-sensitive and -resistant human cancer cell lines.
Cancer Res. 52 (16): 4306-12. -
Johnston, P.G. et al. (1995) Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors.
Cancer Res. 55 (7): 1407-12.
- Synonyms
- TYMS
- RRID
- AB_2288065
- UniProt
- P04818
- Entrez Gene
- TYMS
- GO Terms
- GO:0006260 DNA replication
- GO:0000083 regulation of transcription involved in G1/S phase of mitotic cell cycle
- GO:0005829 cytosol
- GO:0004799 thymidylate synthase activity
- GO:0006206 pyrimidine base metabolic process
- GO:0006281 DNA repair
- GO:0046683 response to organophosphorus
- GO:0048015 phosphatidylinositol-mediated signaling
- GO:0046134 pyrimidine nucleoside biosynthetic process
- View More GO Terms
View more products with Thymidylate Synthase specificity
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
View all Anti-Human ProductsAlways be the first to know.
When we launch new products and resources to help you achieve more in the lab.
Yes, sign me up