TFEB antibody | AB01/2D12
Mouse anti TFEB
- Product Type
- PrecisionAb Monoclonal
- Clone
- AB01/2D12
- Isotype
- IgG1
- Format
- Purified
- Specificity
- TFEB
Antibody Quality and Performance Guarantee
| Mouse anti TFEB antibody recognizes transcription factor EB, also known as bHLHe35. TFEB1 is a transcription factor which plays an important role in cellular processes including lysosomal biogenesis, cellular energy metabolism, lipid catabolism and autophagy. TFEB activity and localization is regulated by mTOR at the surface of lysosomes (Napolitano and Ballabio, 2016). When activated, TFEB controls the expression of genes that regulate biogenesis of lysosomes and autophagosomes (Nnah et al. 2019). Evidence has also shown that TFEB becomes activated in response to mitochondrial and ER stress, suggesting a role in cellular adaptation to stress (Raben and Puertollano 2016). TFEB is upregulated in a range of cancer types including non-Hodgkin's lymphoma. In late-stage colorectal cancer, it is been suggested that TFEB could regulate autophagy and promote tumor growth and metastasis (Liang et al. 2018). |
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- Target Species
- Human
- Western Blotting
- Mouse anti TFEB detects a band of approximately 62 kDa in Raji cell lysates
- Product Form
- Purified IgG - Liquid
- Preparation
- Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- Immunogen
- E. coli-derived recombinant protein of amino acids 1-476 of human TFEB
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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| List Price | Your Price | ||||||
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| Description | Goat anti Mouse IgG (H/L):HRP | ||||||
- UniProt
- P19484
- Entrez Gene
- TFEB
- GO Terms
- GO:0001892 embryonic placenta development
- GO:0003700 sequence-specific DNA binding transcription factor activity
- GO:0005737 cytoplasm
- GO:0006959 humoral immune response
- GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0010843 promoter binding
- GO:0030528 transcription regulator activity
VMA00972
100005855
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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