TDP43 antibody | 2E2-D3

Mouse anti Human TDP43:Preservative Free

Product Type
Monoclonal Antibody
Clone
2E2-D3
Isotype
IgG1
Specificity
TDP43

Product Code Applications Pack Size List Price Your Price Qty
MCA5071Z
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
IF P WB 0.1 mg loader
List Price Your Price
loader
Search for Batch Specific Datasheets

Mouse anti Human TDP43 antibody, clone 2E2-D3 recognizes human TAR DNA-binding protein 43, also known as TDP43. TPD43 is a 414 amino acid ~45 kDa regulator of transcription and splicing.

Two isoforms of TDP43 generated by alternative splicing have been described. Mouse anti Human TDP43 antibody, clone 2E2-D3 binds to the canonical isoform 1. Binding to the truncated isoform 2 which lacks a significant portion of the immunogen sequence used to generate clone 2E2-D3 has not been established.

Mutations in the TDP43 gene can result in the development of Amyotrophic lateral sclerosis 10 (ALS10), A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brainstem and spinal cord, resulting in fatal paralysis (Yokoseki et al. 2008).

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A from ascites
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
None present
Immunogen
Recombinant protein corresponding to aa 1-261 of human TDP43
Approx. Protein Concentrations
Ig concentration 0.5 mg/ml
Fusion Partners
Spleen cells from BALB/c mice were fused with cells from the Sp2/0 myeloma cell line.
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunofluorescence 0.1 10 ug/ml
Immunohistology - Paraffin 0.1 10 ug/ml
Western Blotting 0.1 10 ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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Synonyms
TARDBP
RRID
AB_2255740
UniProt
Q13148
Entrez Gene
TARDBP
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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