SRSF1 antibody | AB01/3A7

Mouse anti SRSF1

Product Type
PrecisionAb Monoclonal
Clone
AB01/3A7
Isotype
IgG2b
Format
Purified
Specificity
SRSF1

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VMA00538
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Mouse anti Human SRSF1 antibody recognizes the serine/arginine-rich splicing factor 1, also known as SR splicing factor 1, alternative-splicing factor 1, pre-mRNA-splicing factor SF2 P33 subunit.

The SRSF1 gene encodes a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for SRSF1. In addition, a pseudogene of SRSF1 has been found on chromosome 13 (provided by RefSeq, Sep 2010).

Mouse anti Human SRSF1 antibody detects a band of 33 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti SRSF1 detects a band of approximately 33 kDa in LNCaP cell lysates.
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody purified by affinity chromatography on Protein G from ascites.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
E. coli-derived recombinant human SRSF1 (amino acids 1 - 248)
Approx. Protein Concentrations
IgG concentration 2.0 mg/ml.
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunoprecipitation
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Description Goat anti Mouse IgG (H/L):HRP

UniProt
Q07955
Entrez Gene
SRSF1
GO Terms
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0003723 RNA binding
GO:0005737 cytoplasm
GO:0005681 spliceosomal complex
GO:0006369 termination of RNA polymerase II transcription
GO:0006376 mRNA splice site selection
GO:0006406 mRNA export from nucleus
GO:0016607 nuclear speck
GO:0031124 mRNA 3'-end processing
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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