Spectrin Alpha Chain antibody
Mouse anti Human spectrin alpha chain antibody recognizes spectrin alpha chain also known as alpha-II spectrin, fodrin alpha chain spectrin and non-erythroid alpha subunit.
Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. The spectrin alpha chain is specifically expressed in non-erythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in the spectrin alpha chain are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants (provided by RefSeq, Sep 2010).
Mouse anti Human spectrin alpha chain antibody detects a band of 285 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. The spectrin alpha chain is specifically expressed in non-erythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in the spectrin alpha chain are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants (provided by RefSeq, Sep 2010).
Mouse anti Human spectrin alpha chain antibody detects a band of 285 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Product Details
- Target Species
- Human
- Western Blotting
- Anti spectrin alpha chain detects a band of approximately 285 kDa in Jurkat cell lysates.
- Product Form
- Purified IgG - liquid
- Preparation
- Mouse monoclonal antibody purified by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- E. Coli derived recombinant protein, aa 1009-1209 of human spectrin alpha chain
Storage Information
- Storage
- Store undiluted at -20oC, avoiding repeated freeze thaw cycles.
- Guarantee
- 12 months from date of despatch
More Information
- UniProt
- Q13813
- Entrez Gene
- SPTAN1
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories.
- Regulatory
- For research purposes only
Applications of Spectrin Alpha Chain antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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