Somatostatin Receptor 5 antibody | sstr5

Mouse anti Human Somatostatin Receptor 5

Product Type
Monoclonal Antibody
Clone
sstr5
Isotype
IgG2b
Specificity
Somatostatin Receptor 5

Product Code Applications Pack Size List Price Your Price Qty
MCA5923
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
P 0.2 mg loader
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loader
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Mouse anti Human Somatostatin Receptor 5 antibody, clone sstr5 recognizes human somatostatin receptor 5 (SS-5-R), a 364 amino acid multi pass transmembrane glycoprotein receptor for Somatostatin-28 and to a lesser extent somatostatin-14. (SST) is a peptide hormone with wide ranging inhibitory effects on hormone secretion and cell proliferation. It is produced as a large preproSST precursor molecule that is cleaved to yield one of two active forms of the peptide: a 14 amino acid peptide (SST-14), or a 28 amino acid peptide (SST-28). The inhibitory effects of SST on hormone release and cell growth have made them candidates for the treatment of cancer and neuroendocrine disorders. Natural SSTs have very short half-lives, which led to the development of more stable synthetic derivatives, such as octreotide and lanreotide, both in common clinical use.

The effects of SST are mediated via five distinct SST receptors (SSTRs). The receptors have similar affinities for natural SST-14 and SST-28, but there are marked differences in affinities towards the synthetic analogues. Somatostatin receptors are expressed by various tissues, notably neuronal, endocrine, gastrointestinal and immune cells, as well as certain tumours, with tumours often expressing more than one subtype in different combinations.

Mouse anti Human Somatostatin Receptor 5 antibody, clone sstr5 specifically recognises SSTR type 5, but none of the other SSTR subtypes. Bio-Rad also has antibodies to SSTR subtypes 1, 3 and 4 (MCA5924, MCA5921, MCA5922) available.

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Antibody purified from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Carrier Free
Yes
Immunogen
Synthetic peptide, sequence CAHRAAANGLMQTSKL.
Approx. Protein Concentrations
IgG concentration 1mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1/100 1/250
Western Blotting
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
Human pancreas

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References for Somatostatin Receptor 5 antibody

  1. Schmid, H.A. et al. (2012) Monoclonal antibodies against the human somatostatin receptor subtypes 1-5: development and immunohistochemical application in neuroendocrine tumors.
    Neuroendocrinology. 95 (3): 232-47.

UniProt
P35346
Entrez Gene
SSTR5
GO Terms
GO:0004994 somatostatin receptor activity
GO:0005887 integral to plasma membrane
GO:0008285 negative regulation of cell proliferation
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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