Somatostatin Receptor 1 antibody | sstr1
Mouse anti Human Somatostatin receptor 1, clone sstr1 recognizes the type I somatostatin receptor also known as SRIF-2. The human somatostatin receptor type 1 is a 391 amino acid, ~50 kDa multi pass transmembrane glycoprotein belonging to the G-protein coupled receptor 1 family.
Somatostatin (SST) is a peptide hormone with wide ranging inhibitory effects on hormone secretion and cell proliferation. It is produced as a large preproSST precursor molecule that is cleaved to yield one of two active forms of the peptide: a 14 amino acid peptide (SST-14), or a 28 amino acid peptide (SST-28). The inhibitory effects of SST on hormone release and cell growth have made them candidates for the treatment of cancer and neuroendocrine disorders. Natural SSTs have very short half-lives, which led to the development of more stable synthetic derivatives, such as octreotide and lanreotide, both in common clinical use.
The effects of SST are mediated via five distinct SST receptors (SSTRs). The receptors have similar affinities for natural SST-14 and SST-28, but there are marked differences in affinities towards the synthetic analogues. Somatostatin receptors are expressed by various tissues, notably neuronal, endocrine, gastrointestinal and immune cells, as well as certain tumours, with tumours often expressing more than one subtype in different combinations.
Clone sstr1 specifically recognises SSTR type 1, but none of the other SSTR subtypes. Bio-Rad also has antibodies to other somatostatin receptors available
Somatostatin (SST) is a peptide hormone with wide ranging inhibitory effects on hormone secretion and cell proliferation. It is produced as a large preproSST precursor molecule that is cleaved to yield one of two active forms of the peptide: a 14 amino acid peptide (SST-14), or a 28 amino acid peptide (SST-28). The inhibitory effects of SST on hormone release and cell growth have made them candidates for the treatment of cancer and neuroendocrine disorders. Natural SSTs have very short half-lives, which led to the development of more stable synthetic derivatives, such as octreotide and lanreotide, both in common clinical use.
The effects of SST are mediated via five distinct SST receptors (SSTRs). The receptors have similar affinities for natural SST-14 and SST-28, but there are marked differences in affinities towards the synthetic analogues. Somatostatin receptors are expressed by various tissues, notably neuronal, endocrine, gastrointestinal and immune cells, as well as certain tumours, with tumours often expressing more than one subtype in different combinations.
Clone sstr1 specifically recognises SSTR type 1, but none of the other SSTR subtypes. Bio-Rad also has antibodies to other somatostatin receptors available
Product Details
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Carrier Free
- Yes
- Immunogen
- Synthetic peptide, sequence CKSRAYSVEDFQPENLE
- Approx. Protein Concentrations
- IgG concentration 1mg/ml
Storage Information
- Storage
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P30872
- Entrez Gene
- SSTR1
- GO Terms
- GO:0004994 somatostatin receptor activity
- GO:0005887 integral to plasma membrane
- GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger
- GO:0007584 response to nutrient
- GO:0007586 digestion
- GO:0008285 negative regulation of cell proliferation
- Regulatory
- For research purposes only
Applications of Somatostatin Receptor 1 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin | 1/100 | 1/250 | |
| Western Blotting |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Histology Positive Control Tissue
- Human pancreas
Copyright © 2021 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
Product Specific References
References for Somatostatin Receptor 1 antibody
-
Schmid, H.A. et al. (2012) Monoclonal antibodies against the human somatostatin receptor subtypes 1-5: development and immunohistochemical application in neuroendocrine tumors.
Neuroendocrinology. 95 (3): 232-47. -
Ozkaya, H.M. et al. (2018) Germline mutations of aryl hydrocarbon receptor-interacting protein (AIP) gene and somatostatin receptor 1-5 and AIP immunostaining in patients with sporadic acromegaly with poor versus good response to somatostatin analogues.
Pituitary. 21 (4): 335-6. -
Leijon, H. et al. (2018) Variable somatostatin receptor subtype expression in 151 primary pheochromocytomas and paragangliomas.
Hum Pathol. Dec 07 [Epub ahead of print].
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