SNW1 antibody | CD02/1B11

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Anti SNW1 Antibody, clone CD02/1B11 (PrecisionAb Monoclonal Antibody) thumbnail image 1

Anti SNW1 Antibody, clone CD02/1B11 (PrecisionAb Monoclonal Antibody) thumbnail image 2

Anti SNW1 Antibody, clone CD02/1B11 (PrecisionAb Monoclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with SNW1 antibody (1/1000, **VMA00947**) followed by detection with HRP conjugated Goat anti Mouse IgG (1/5000, STAR207P) and visualized on the ChemiDoc MP. Arrow points to SNW1 (molecular weight 62 kDa)

Anti SNW1 Antibody, clone CD02/1B11 (PrecisionAb Monoclonal Antibody) gallery image 2 — Western blot analysis of whole cell lysates probed with SNW1 antibody (1/500, **VMA00947**) followed by detection with HRP conjugated Goat anti Mouse IgG (1/5000, STAR207P) and visualized on the ChemiDoc MP. Arrow points to SNW1 (molecular weight 62 kDa)

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Mouse anti SNW1

Product Type: PrecisionAb Monoclonal
Clone: CD02/1B11
Isotype: IgG1
Format: Purified
Specificity: SNW1

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Product Code Applications Pack Size List Price Your Price Qty

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VMA00947 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Mouse anti SNW1 antibody recognizes SNW domain-containing protein 1, also known as SKIIP, SKIP. SNW1 is a multifunctional protein which can act by direct protein interactions, by regulation of mRNA splicing, or regulation of transcription (Hoflmayer et al. 2019). To regulate mRNA splicing, SNW1 forms a component of the spliceosome which removes intronic sequences from pre-mRNAs before export of mature mRNA from the nucleus (van der Lelij et al. 2014). SNW1 is recruited to pre-mRNA after U1 and U4 snRNPs dissociate from the spliceosome. To regulate transcription, SNW1 is able to associate with numerous transcription factors to modulate their activities (Sato et al. 2015). SNW1 overexpression has been associated with poor prognosis in a variety of cancer types, and is upregulated in types of breast cancer, liver cancer, bladder cancer and malignant pleural mesothelioma (Hoflmayer et al. 2019). In embryogenesis, SNW1 is essential for defining the edge of the neural plate where the neural crest is specified (Wu et al. 2011).

Target Species: Human
Western Blotting: Mouse anti SNW1 detects a band of approximately 62 kDa in HEK293 cell lysates
Product Form: Purified IgG - Liquid
Preparation: Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution: Phosphate buffered saline
Preservative Stabilisers: 0.09% Sodium Azide
Immunogen: E. coli-derived recombinant protein of amino acids 271-536 of human SNW1
Approx. Protein Concentrations: IgG concentration 1.0 mg/ml
Fusion Partners: Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Regulatory: For research purposes only
Guarantee: 12 months from date of despatch
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/500	1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Mouse IgG (H/L):HRP	STAR207P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Mouse IgG (H/L):HRP

UniProt: Q13573
Entrez Gene: SNW1
GO Terms: GO:0000398 nuclear mRNA splicing, via spliceosome; GO:0005112 Notch binding; GO:0005654 nucleoplasm; GO:0005681 spliceosomal complex; GO:0006357 regulation of transcription from RNA polymerase II promoter; GO:0016564 transcription repressor activity