SNW1 antibody | CD02/1B11

Mouse anti SNW1

Product Type
PrecisionAb Monoclonal
Clone
CD02/1B11
Isotype
IgG1
Format
Purified
Specificity
SNW1

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VMA00947
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Mouse anti SNW1 antibody recognizes SNW domain-containing protein 1, also known as SKIIP, SKIP. SNW1 is a multifunctional protein which can act by direct protein interactions, by regulation of mRNA splicing, or regulation of transcription (Hoflmayer et al. 2019). To regulate mRNA splicing, SNW1 forms a component of the spliceosome which removes intronic sequences from pre-mRNAs before export of mature mRNA from the nucleus (van der Lelij et al. 2014). SNW1 is recruited to pre-mRNA after U1 and U4 snRNPs dissociate from the spliceosome. To regulate transcription, SNW1 is able to associate with numerous transcription factors to modulate their activities (Sato et al. 2015). SNW1 overexpression has been associated with poor prognosis in a variety of cancer types, and is upregulated in types of breast cancer, liver cancer, bladder cancer and malignant pleural mesothelioma (Hoflmayer et al. 2019). In embryogenesis, SNW1 is essential for defining the edge of the neural plate where the neural crest is specified (Wu et al. 2011). PrecisionAb Antibodies

Target Species
Human
Western Blotting
Mouse anti SNW1 detects a band of approximately 62 kDa in HEK293 cell lysates
Product Form
Purified IgG - Liquid
Preparation
Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
Immunogen
E. coli-derived recombinant protein of amino acids 271-536 of human SNW1
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/500 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml loader
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Description Goat anti Mouse IgG (H/L):HRP

UniProt
Q13573
Entrez Gene
SNW1
GO Terms
GO:0000398 nuclear mRNA splicing, via spliceosome
GO:0005112 Notch binding
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0016564 transcription repressor activity
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