SNW1 antibody | CD02/1B11
Mouse anti SNW1 antibody recognizes SNW domain-containing protein 1, also known as SKIIP, SKIP. SNW1 is a multifunctional protein which can act by direct protein interactions, by regulation of mRNA splicing, or regulation of transcription (Hoflmayer et al. 2019). To regulate mRNA splicing, SNW1 forms a component of the spliceosome which removes intronic sequences from pre-mRNAs before export of mature mRNA from the nucleus (van der Lelij et al. 2014). SNW1 is recruited to pre-mRNA after U1 and U4 snRNPs dissociate from the spliceosome. To regulate transcription, SNW1 is able to associate with numerous transcription factors to modulate their activities (Sato et al. 2015). SNW1 overexpression has been associated with poor prognosis in a variety of cancer types, and is upregulated in types of breast cancer, liver cancer, bladder cancer and malignant pleural mesothelioma (Hoflmayer et al. 2019). In embryogenesis, SNW1 is essential for defining the edge of the neural plate where the neural crest is specified (Wu et al. 2011).
Product Details
- Target Species
- Human
- Western Blotting
- Mouse anti SNW1 detects a band of approximately 62 kDa in HEK293 cell lysates
- Product Form
- Purified IgG - Liquid
- Preparation
- Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- Immunogen
- E. coli-derived recombinant protein of amino acids 271-536 of human SNW1
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Storage Information
- Storage
- Store undiluted at -20°C, avoiding repeated freeze thaw cycles
- Guarantee
- 12 months from date of despatch
More Information
- UniProt
- Q13573
- Entrez Gene
- SNW1
- GO Terms
- GO:0000398 nuclear mRNA splicing, via spliceosome
- GO:0005112 Notch binding
- GO:0005654 nucleoplasm
- GO:0005681 spliceosomal complex
- GO:0006357 regulation of transcription from RNA polymerase II promoter
- GO:0016564 transcription repressor activity
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
- Regulatory
- For research purposes only
Applications of SNW1 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/500 | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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