SNW1 antibody | CD02/1B11
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WB ResetMouse anti SNW1
- Product Type
- PrecisionAb Monoclonal
- Clone
- CD02/1B11
- Isotype
- IgG1
- Format
- Purified
- Specificity
- SNW1
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| Mouse anti SNW1 antibody recognizes SNW domain-containing protein 1, also known as SKIIP, SKIP. SNW1 is a multifunctional protein which can act by direct protein interactions, by regulation of mRNA splicing, or regulation of transcription (Hoflmayer et al. 2019). To regulate mRNA splicing, SNW1 forms a component of the spliceosome which removes intronic sequences from pre-mRNAs before export of mature mRNA from the nucleus (van der Lelij et al. 2014). SNW1 is recruited to pre-mRNA after U1 and U4 snRNPs dissociate from the spliceosome. To regulate transcription, SNW1 is able to associate with numerous transcription factors to modulate their activities (Sato et al. 2015). SNW1 overexpression has been associated with poor prognosis in a variety of cancer types, and is upregulated in types of breast cancer, liver cancer, bladder cancer and malignant pleural mesothelioma (Hoflmayer et al. 2019). In embryogenesis, SNW1 is essential for defining the edge of the neural plate where the neural crest is specified (Wu et al. 2011). |
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- Target Species
- Human
- Western Blotting
- Mouse anti SNW1 detects a band of approximately 62 kDa in HEK293 cell lysates
- Product Form
- Purified IgG - Liquid
- Preparation
- Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- Immunogen
- E. coli-derived recombinant protein of amino acids 271-536 of human SNW1
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/500 | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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| List Price | Your Price | ||||||
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| Description | Goat anti Mouse IgG (H/L):HRP | ||||||
- UniProt
- Q13573
- Entrez Gene
- SNW1
- GO Terms
- GO:0000398 nuclear mRNA splicing, via spliceosome
- GO:0005112 Notch binding
- GO:0005654 nucleoplasm
- GO:0005681 spliceosomal complex
- GO:0006357 regulation of transcription from RNA polymerase II promoter
- GO:0016564 transcription repressor activity
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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