SIRT6 antibody | EF01/2A11
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WB ResetMouse anti SIRT6
- Product Type
- PrecisionAb Monoclonal
- Clone
- EF01/2A11
- Isotype
- IgG1
- Format
- Purified
- Specificity
- SIRT6
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Antibody Quality and 
Unrivaled 
| Mouse anti SIRT6 antibody recognizes NAD-dependent protein deacetylase sirtuin-6, also known as regulatory protein SIR2 homolog 6. SIRT6 is a NAD+-dependent deacetylase which belongs to the sirtuin family. As a histone deacetylase, SIRT6 targets specific sites on histone H3 and regulates chromatin compaction, transcriptional repression and DNA damage responses. The protein has multiple targets, and through its deacetylase activity, plays roles in chromatin signaling and genome maintenance (Tasselli et al. 2016). SIRT6 can be found in the nucleus and in the cytoplasm, and localizes to cytoplasmic stress granules in response to stress (D'Onofrio et al. 2018). SIRT6 protects against aging-associated pathologies such as metabolic disease and cancer (Tasselli et al. 2016). SIRT6 appears to have a protective role against obesity and diabetes, with deficiency of SIRT6 leading to liver steatosis, diet-induced obesity and diabetes (Kuang et al. 2018). |
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- Target Species
- Human
- Western Blotting
- Mouse anti SIRT6 detects a band of approximately 40 kDa in Jurkat cell lysates
- Species Cross-Reactivity
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Target Species Cross Reactivity Mouse Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - Liquid
- Preparation
- Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- Immunogen
- E. coli-derived recombinant protein of amino acids 1-353 of human SIRT6
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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| List Price | Your Price | ||||||
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| Description | Goat anti Mouse IgG (H/L):HRP | ||||||
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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