SH3KBP1 antibody | rAB01-4D6

Mouse anti SH3KBP1

Product Type
PrecisionAb Monoclonal
Clone
rAB01-4D6
Isotype
IgG2a
Format
Purified
Specificity
SH3KBP1

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VMA00904
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Mouse anti SH3KBP1 antibody recognizes SH3 domain-containing kinase-binding protein 1, also known as CIN85 and CD2BP3.

SH3KBP1 is a ubiquitously-expressed, multifunctional adaptor protein involved with regulation of multiple cellular housekeeping processes and cell type-specific functions. Central cell functions with SH3KBP1 involvement include vesicle trafficking, cytoskeletal organization, and cell surface receptor signaling (Keller et al. 2018). The multi-functional abilities of SH3KBP1 can be attributed to its multiple protein-protein binding motifs, allowing SH3KBP1 to interact with a wide range of signaling molecules within vast intracellular networks (Teng et al. 2016). SH3KBP1 is also an adaptor of EGFR and is pro-oncogenic, affecting apoptosis, adhesion, and invasion. It promotes cancer development and is overexpressed in the most hypoxic areas of tissues (Kozlova et al. 2019).
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Mouse anti SH3KBP1 antibody detects a band of approximately 78 and 84 kDa in THP-1 cell lysates
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Recombinant IgG prepared by affinity chromatography on Protein A from cell culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
E. coli--derived recombinant protein of amino acids 366-665 of human SH3KBP1
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Regulatory
For research purposes only
Guarantee
As supplied, 12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20oC, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/2000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

UniProt
Q96B97
Entrez Gene
SH3KBP1
GO Terms
GO:0006915 apoptosis
GO:0005829 cytosol
GO:0005634 nucleus
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0006897 endocytosis
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0017124 SH3 domain binding
GO:0019717 synaptosome
GO:0030659 cytoplasmic vesicle membrane
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0045202 synapse
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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