SGK3 antibody | 2A7

Mouse anti Human SGK3:Preservative Free

Product Type
Monoclonal Antibody
Clone
2A7
Isotype
IgG2b
Specificity
SGK3

Product Code Applications Pack Size List Price Your Price Qty
MCA5480Z
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
P 0.1 mg loader
List Price Your Price
loader
Search for Batch Specific Datasheets

Mouse anti Human SGK3 antibody, clone 2A7 recognizes human Serine/threonine-protein kinase Sgk3 also known as Cytokine-independent survival kinase, Serum/glucocorticoid-regulated kinase 3 or SGK3. Serine/threonine-protein kinase Sgk3 is a 496 amino acid endosomal protein involved in regulation of multiple ion channels, membrane transporters and cell growth, proliferation, survival and migration. SGK3 contains single AGC-kinase, C-terminal; protein kinase; and PX (phox homology) domains.

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A from ascites
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
None present
Immunogen
Recombinant protein corresponding to aa 1 - 130 of human SGK3
Approx. Protein Concentrations
Ig concentration 0.5 mg/ml
Fusion Partners
Spleen cells from BALB/c mice were fused with cells from the Sp2/0 myeloma cell line.
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 0.1 10 ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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References for SGK3 antibody

  1. Wang, Y. et al. (2011) SGK3 Is an Estrogen-Inducible Kinase Promoting Estrogen-Mediated Survival of Breast Cancer Cells.
    Mol Endocrinol. 25: 72-82
  2. Wang, Y. et al. (2014) Coordinated regulation of serum- and glucocorticoid-inducible kinase 3 by a C-terminal hydrophobic motif and Hsp90-Cdc37 chaperone complex.
    J Biol Chem. 289 (8): 4815-26.
  3. Wang, Y. et al. (2014) SGK3 is an androgen-inducible kinase promoting prostate cancer cell proliferation through activation of p70 S6 kinase and up-regulation of cyclin D1.
    Mol Endocrinol. me20131339.
  4. Vasudevan, K.M. et al. (2009) AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.
    Cancer Cell. 16 (1): 21-32.

Western Blotting

Synonyms
SGKL
RRID
AB_2239231
UniProt
Q96BR1
Entrez Gene
C8orf44-SGK3
GO Terms
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005769 early endosome
GO:0006468 protein phosphorylation
GO:0006950 response to stress
GO:0007154 cell communication
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0035091 phosphatidylinositol binding
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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