SERPINH1 antibody | AB01/3C1
Mouse anti SERPINH1
- Product Type
- PrecisionAb Monoclonal
- Clone
- AB01/3C1
- Isotype
- IgG2a
- Format
- Purified
- Specificity
- SERPINH1
Mouse anti SERPINH1 antibody recognizes serpin H1, also known as HSP47, AsTP3 and colligin. SERPINH1 is a member of the serpin superfamily of protease inhibitors, critical for control of many proteolytic cascades including the coagulation cascade in mammals (Law et al. 2006). SERPINH1 is a key regulator of collagen synthesis. It is essential for appropriate folding of pro-collagen in the endoplasmic reticulum, and by association is involved with embryonic development (Kumar et al. 2017). SERPINH1 and has been implicated in collagen-related diseases including brittle bone disease, keloid scars and lung fibrosis (Tian et al. 2020). SERPINH1 is highly expressed in a range of cancers including pancreatic cancer, glioma, and clear cell renal cell carcinoma, and can drive malignant behaviour of cancer cells (Qi et al. 2018). |
- Target Species
- Human
- Western Blotting
- Mouse anti SERPINH1 detects a band of approximately 44 kDa in HeLa cell lysates
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - Liquid
- Preparation
- Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- Immunogen
- E. coli-derived recombinant protein of amino acids 19-418 of human SERPINH1
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml | Log in | |||
List Price | Your Price | ||||||
Log in | |||||||
Description | Goat anti Mouse IgG (H/L):HRP |
- UniProt
- P50454
- Entrez Gene
- SERPINH1
- GO Terms
- GO:0006986 response to unfolded protein
- GO:0004867 serine-type endopeptidase inhibitor activity
- GO:0005518 collagen binding
- GO:0005788 endoplasmic reticulum lumen
- GO:0005793 ER-Golgi intermediate compartment
VMA00970
100005794If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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