Rabbit anti SATB2 antibody
recognizes DNA-binding protein SATB2, also known as special AT-rich sequence-binding protein 2.
SATB2 is a transcription factor which can bind to matrix-attachment regions (MARs) and activate transcription of multiple genes simultaneously. This allows SATB2 to act as a high-level regulator of multiple networks involved with development (Zarate and Fish 2016
). SATB2 is highly expressed in the brain and plays a role in development of the central nervous system and neocortical organization. It also plays a role in differentiation of osteoblasts (Berg et al. 2016
). Mutations in the gene encoding SATB2 can lead to SATB2-associated syndrome, characterized by developmental delay, intellectual disability, speech and behavioural problems, and craniofacial abnormalities (Whitton et al. 2018
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from animal origin-free culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
1% Bovine Serum Albumin
- A peptide corresponding to the C-terminus of human DNA-binding protein SATB2
- Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
sequence-specific DNA binding transcription factor activity
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of SATB2 antibody
|Immunohistology - Paraffin
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
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