RHOC antibody | OTI3A5

Mouse anti RHOC

Product Type
PrecisionAb Monoclonal
Clone
OTI3A5
Isotype
IgG2b
Format
Purified
Specificity
RHOC

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VMA00392
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Mouse anti Human RHOC antibody, clone OTI3A5 recognizes the Rho-related GTP-binding protein RhoC, also known as RAS-related homolog 9, oncogene RHO H9, rhoC GTPase and small GTP binding protein RhoC.

RHOC encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by the RHOC gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of RHOC is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified (provided by RefSeq, Jul 2008).

Mouse anti Human RHOC antibody detects a band of 21 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti RHOC detects a band of approximately 21 kDa in LNCaP cell lysates.
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody purified by affinity chromatography from ascites.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
50% Glycerol
Immunogen
Synthetic peptide (VFEMATRAGLQVRKNKRRRG) corresponding to the C-terminal of human RHOC
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml loader
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Description Goat anti Mouse IgG (H/L):HRP

UniProt
P08134
Entrez Gene
RHOC
GO Terms
GO:0005886 plasma membrane
GO:0005515 protein binding
GO:0003924 GTPase activity
GO:0005829 cytosol
GO:0004871 signal transducer activity
GO:0005525 GTP binding
GO:0007264 small GTPase mediated signal transduction
GO:0007411 axon guidance
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0051056 regulation of small GTPase mediated signal transduction
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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