RBM8A antibody | AB02/4G3

Mouse anti RBM8A

Product Type
PrecisionAb Monoclonal
Clone
AB02/4G3
Isotype
IgG2b
Format
Purified
Specificity
RBM8A

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VMA00939
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Mouse anti RBM8A antibody recognizes RNA-binding protein 8A, also known as ribonucleoprotein RBM8A and Y14.

RBM8A binds to RNA and controls a diverse range of functions including gene expression, cell cycle progression, apoptosis and RNA splicing. This regulation is acheived by employing cancer-related kinases, miRNAs and the E2F1 transcription factor (Lin et al. 2019). Loss of RBM8A leads to increased apoptosis and inhibits cell proliferation. RBM8A is overexpressed in hepatocellular carcinoma (HCC) tissues, and is associated with poor prognosis in patients with HCC (Liang et al. 2017). A role for RBM8A has been suggested in neurodevelopment, and implicated in risk of autism and schizophrenia (Zou et al. 2015). Furthermore, in mice, overexpression of RBM8A led to increased anxiety-like behavior and abnormal social behavior (Alachkar et al. 2013).
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Mouse anti RBM8A detects a band of approximately 20 kDa in Jurkat cell lysates
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - Liquid
Preparation
Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
Immunogen
E. coli-derived recombinant protein of amino acids 1-174 of human RBM8A
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml loader
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Description Goat anti Mouse IgG (H/L):HRP

UniProt
Q9Y5S9
Entrez Gene
RBM8A
GO Terms
GO:0000166 nucleotide binding
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0005515 protein binding
GO:0000398 nuclear mRNA splicing, via spliceosome
GO:0003729 mRNA binding
GO:0005829 cytosol
GO:0005681 spliceosomal complex
GO:0006369 termination of RNA polymerase II transcription
GO:0006406 mRNA export from nucleus
GO:0006417 regulation of translation
GO:0016607 nuclear speck
GO:0031124 mRNA 3'-end processing
GO:0035145 exon-exon junction complex
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