RBM8A antibody | AB02/4G3
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WB ResetMouse anti RBM8A
- Product Type
- PrecisionAb Monoclonal
- Clone
- AB02/4G3
- Isotype
- IgG2b
- Format
- Purified
- Specificity
- RBM8A
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| Mouse anti RBM8A antibody recognizes RNA-binding protein 8A, also known as ribonucleoprotein RBM8A and Y14. RBM8A binds to RNA and controls a diverse range of functions including gene expression, cell cycle progression, apoptosis and RNA splicing. This regulation is acheived by employing cancer-related kinases, miRNAs and the E2F1 transcription factor (Lin et al. 2019). Loss of RBM8A leads to increased apoptosis and inhibits cell proliferation. RBM8A is overexpressed in hepatocellular carcinoma (HCC) tissues, and is associated with poor prognosis in patients with HCC (Liang et al. 2017). A role for RBM8A has been suggested in neurodevelopment, and implicated in risk of autism and schizophrenia (Zou et al. 2015). Furthermore, in mice, overexpression of RBM8A led to increased anxiety-like behavior and abnormal social behavior (Alachkar et al. 2013). |
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- Target Species
- Human
- Western Blotting
- Mouse anti RBM8A detects a band of approximately 20 kDa in Jurkat cell lysates
- Species Cross-Reactivity
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Target Species Cross Reactivity Mouse Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - Liquid
- Preparation
- Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- Immunogen
- E. coli-derived recombinant protein of amino acids 1-174 of human RBM8A
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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| List Price | Your Price | ||||||
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| Description | Goat anti Mouse IgG (H/L):HRP | ||||||
- UniProt
- Q9Y5S9
- Entrez Gene
- RBM8A
- GO Terms
- GO:0000166 nucleotide binding
- GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- GO:0005515 protein binding
- GO:0000398 nuclear mRNA splicing, via spliceosome
- GO:0003729 mRNA binding
- GO:0005829 cytosol
- GO:0005681 spliceosomal complex
- GO:0006369 termination of RNA polymerase II transcription
- GO:0006406 mRNA export from nucleus
- View More GO Terms
- GO:0006417 regulation of translation
- GO:0016607 nuclear speck
- GO:0031124 mRNA 3'-end processing
- GO:0035145 exon-exon junction complex
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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