RANTES antibody | OTI2A7

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Mouse anti RANTES

RANTES antibody recognizes RANTES, also known as C-C motif chemokine 5, beta-chemokine RANTES, or CCL5.

Product Type
PrecisionAb™ Monoclonal
Clone
OTI2A7
Isotype
IgG1
Format
Purified
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
VMA00692 WB 100 µl
Mouse anti Human RANTES antibody recognizes RANTES, also known as C-C motif chemokine 5, beta-chemokine RANTES and CCL5.

CCL5 is a member of the CC subfamily of chemokines that functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It acts as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5) and suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor (provided by RefSeq, Jul 2013).

Mouse anti Human RANTES antibody detects a band of 10 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Product Details

Target Species
Human
Western Blotting
Mouse anti RANTES detects a band of approximately 10 kDa in differentiated THP-1 cells stimulated for 16 hrs with lipopolysaccharide (LPS)
Product Form
Purified IgG - Liquid
Preparation
Mouse monoclonal antibody affinity purified on immunogen from ascites
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
Immunogen
HEK293-dervied full length human recombinant protein of human RANTES
Instructions For Use
Please refer to the PrecisionAb western blotting protocol. For additional information on secondary antibody dilution and exposure time see product web page.

Storage Information

Storage
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
Shelf Life
As supplied, 12 months from date of despatch

More Information

UniProt
P13501 Related reagents
Entrez Gene
CCL5 Related reagents
GO Terms
GO:0009615 response to virus
GO:0007155 cell adhesion
GO:0004871 signal transducer activity
GO:0005615 extracellular space
GO:0006874 cellular calcium ion homeostasis
GO:0006887 exocytosis
GO:0006955 immune response
GO:0006968 cellular defense response
GO:0006979 response to oxidative stress
GO:0007267 cell-cell signaling
GO:0008009 chemokine activity
GO:0042056 chemoattractant activity
GO:0045071 negative regulation of viral genome replication
Acknowledgements
PrecisionAb™ is a trademark of Bio-Rad Laboratories
Regulatory
For research purposes only

Applications of RANTES antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

PrecisionAb antibodies have been extensively validated for the western blot application. The antibody has been validated at the suggested dilution. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependant on sample type.

Secondary Antibodies Available

Description Product Code Pack Size Applications List Price Quantity
Goat anti Mouse IgG (H/L):HRP STAR207P 2 ml WB

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