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PTPN6 antibody | AB01/4C6-1

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Anti PTPN6 Antibody, clone AB01/4C6-1 (PrecisionAb Monoclonal Antibody) thumbnail image 1
Anti PTPN6 Antibody, clone AB01/4C6-1 (PrecisionAb Monoclonal Antibody) gallery image 1
Western blot analysis of whole cell lysates probed with Mouse anti Human PTPN6 antibody, clone AB01/4C6-1 (VMA00629) followed by detection with HRP conjugated Goat anti Mouse IgG (1/10,000, STAR207P) and visualized on the ChemiDoc MP with 11 second exposure. Arrow points to PTPN6 (molecular weight 64 kDa).

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WB

Mouse anti PTPN6

Product Type
PrecisionAb Monoclonal
Clone
AB01/4C6-1
Isotype
IgG1
Format
Purified
Specificity
PTPN6

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Product Code Applications Pack Size List Price Your Price Qty
VMA00629
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SDS Safety Datasheet SDS
WB 100 µl loader
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Mouse anti Human PTPN6 antibody, clone AB01/4C6-1 recognizes PTPN6, also known as SHP1, HCP, tyrosine-protein phosphatase non-receptor type 6 or hematopoietic cell phophatase.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported (provided by RefSeq, Jul 2008).

Mouse anti Human PTPN6 antibody, clone AB01/4C6-1 detects a band of 64 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.		 PrecisionAb Antibodies

Target Species
Human
Western Blotting
Mouse anti PTPN6 antibody detects a band of approximately 64 kDa in HEK293 cell lysates.
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody purified by affinity chromatograpy on Protein G from tissue culture supernatant.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
E. coli-derived recombinant human PTPN6 (aa 391-595)
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description Product Code Applications Pack Size List Price Your Price Quantity
Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml
List Price Your Price
Description Goat anti Mouse IgG (H/L):HRP

UniProt
P29350
Entrez Gene
PTPN6
GO Terms
GO:0005515 protein binding
GO:0016020 membrane
GO:0006915 apoptosis
GO:0005829 cytosol
GO:0004725 protein tyrosine phosphatase activity
GO:0005634 nucleus
GO:0006470 protein dephosphorylation
GO:0007186 G-protein coupled receptor protein signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase cascade
GO:0030168 platelet activation
GO:0031295 T cell costimulation
GO:0034329 cell junction assembly
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0050900 leukocyte migration
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon-mediated signaling pathway
GO:0060338 regulation of type I interferon-mediated signaling pathway
GO:2000045 regulation of G1/S transition of mitotic cell cycle

VMA00629

170517

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