PSMA7 antibody | CD01/4D5

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Mouse anti PSMA7

Product Type
PrecisionAb Monoclonal
Clone
CD01/4D5
Isotype
IgG1
Format
Purified
Product Code Applications Pack Size List Price Quantity
VMA00821
Datasheet
WB
SDS
100 µl loader

Mouse anti PSMA7 antibody recognizes proteasome subunit alpha type-7, also known as XAPC7 and HSPC.

PSMA7 is a multifunctional protein which forms a subunit of the 20S proteasome core complex, playing a role in degradation of proteins through the ubituitin-proteasome pathway (Xia et al. 2019). The gene encoding PSMA7 is involved with inflammation and immunity, and is associated with major depressive disorder and reduction of patient responses to some drugs. It has also been identified as a biomarker for colorectal cancer and inflammatory bowel disease (IBD) (Zheng et al. 2017). PSMA7 is involved with the development and progression of several types of malignancy, and interacts with several proteins involved in tumorigenesis including HIF1-alpha (Xia et al. 2019). In colorectal cancer, PSMA7 forms a complex with NOD1 which may promote cancer progression, and PSMA7 has been suggested as a potential target for tumors that are caused by NOD1 dysfunction (Yang et al. 2013).

Product Details

Target Species
Human
Western Blotting
Mouse anti PSMA7 antibody detects a band of approximately 27 kDa in HEK293 cell lysates
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - Liquid
Preparation
Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
Immunogen
E. coli-derived recombinant protein of amino acids 1-248 of human PSMA7
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line

Storage Information

Storage
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
Guarantee
12 months from date of despatch

More Information

UniProt
O14818
Entrez Gene
PSMA7
GO Terms
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000084 S phase of mitotic cell cycle
GO:0000216 M/G1 transition of mitotic cell cycle
GO:0006915 apoptosis
GO:0004298 threonine-type endopeptidase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006521 regulation of cellular amino acid metabolic process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0042802 identical protein binding
GO:0016032 viral reproduction
GO:0016071 mRNA metabolic process
GO:0042981 regulation of apoptosis
GO:0019773 proteasome core complex, alpha-subunit complex
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0044419 interspecies interaction between organisms
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories
Regulatory
For research purposes only

Applications of PSMA7 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml

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