PSMA7 antibody | CD01/4D5

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Anti PSMA7 Antibody, clone CD01/4D5 (PrecisionAb Monoclonal Antibody) thumbnail image 1

Anti PSMA7 Antibody, clone CD01/4D5 (PrecisionAb Monoclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with PSMA7 antibody (1/1000, **VMA00821**) followed by detection with HRP conjugated Goat anti Mouse IgG (1/10,000, STAR207P) and visualized on the ChemiDoc MP. Arrow points to PSMA7 (molecular weight 27 kDa)

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Mouse anti PSMA7

Product Type: PrecisionAb Monoclonal
Clone: CD01/4D5
Isotype: IgG1
Format: Purified
Specificity: PSMA7

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Product Code Applications Pack Size List Price Your Price Qty

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VMA00821 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Mouse anti PSMA7 antibody recognizes proteasome subunit alpha type-7, also known as XAPC7 and HSPC.

PSMA7 is a multifunctional protein which forms a subunit of the 20S proteasome core complex, playing a role in degradation of proteins through the ubituitin-proteasome pathway (Xia et al. 2019). The gene encoding PSMA7 is involved with inflammation and immunity, and is associated with major depressive disorder and reduction of patient responses to some drugs. It has also been identified as a biomarker for colorectal cancer and inflammatory bowel disease (IBD) (Zheng et al. 2017). PSMA7 is involved with the development and progression of several types of malignancy, and interacts with several proteins involved in tumorigenesis including HIF1-alpha (Xia et al. 2019). In colorectal cancer, PSMA7 forms a complex with NOD1 which may promote cancer progression, and PSMA7 has been suggested as a potential target for tumors that are caused by NOD1 dysfunction (Yang et al. 2013).

Target Species: Human
Western Blotting: Mouse anti PSMA7 antibody detects a band of approximately 27 kDa in HEK293 cell lysates
Species Cross-Reactivity: Target Species Cross Reactivity

Mouse; N.B. Antibody reactivity and working conditions may vary between species.
Product Form: Purified IgG - Liquid
Preparation: Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution: Phosphate buffered saline
Preservative Stabilisers: 0.09% Sodium Azide
Immunogen: E. coli-derived recombinant protein of amino acids 1-248 of human PSMA7
Approx. Protein Concentrations: IgG concentration 1.0 mg/ml
Fusion Partners: Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Regulatory: For research purposes only
Guarantee: 12 months from date of despatch
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories

Target Species	Cross Reactivity
Mouse

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting			1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Mouse IgG (H/L):HRP	STAR207P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Mouse IgG (H/L):HRP

UniProt: O14818
Entrez Gene: PSMA7
GO Terms: GO:0000082 G1/S transition of mitotic cell cycle; GO:0000084 S phase of mitotic cell cycle; GO:0000216 M/G1 transition of mitotic cell cycle; GO:0006915 apoptosis; GO:0004298 threonine-type endopeptidase activity; GO:0005634 nucleus; GO:0005737 cytoplasm; GO:0006521 regulation of cellular amino acid metabolic process; GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; View More GO Terms; GO:0042802 identical protein binding; GO:0016032 viral reproduction; GO:0016071 mRNA metabolic process; GO:0042981 regulation of apoptosis; GO:0019773 proteasome core complex, alpha-subunit complex; GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; GO:0044419 interspecies interaction between organisms; GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle