PSMA1 antibody | CD01/1C10

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Anti PSMA1 Antibody, clone CD01/1C10 (PrecisionAb Monoclonal Antibody) thumbnail image 1

Anti PSMA1 Antibody, clone CD01/1C10 (PrecisionAb Monoclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with PSMA1 antibody (1/1000, **VMA00953**) followed by detection with HRP conjugated Goat anti Mouse IgG (1/10000, STAR207P) and visualized on the ChemiDoc MP. Arrow points to PSMA1 (molecular weight 29 kDa)

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Mouse anti PSMA1

Product Type: PrecisionAb Monoclonal
Clone: CD01/1C10
Isotype: IgG1
Format: Purified
Specificity: PSMA1

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Product Code Applications Pack Size List Price Your Price Qty

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VMA00953 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Mouse anti PSMA1 antibody recognizes proteasome subunit alpha type-1, also known as HC2, PROS30, PSC2. PSMA1 is one of the 17 essential subunits of the 20S proteasome, a complex which has critical roles in regulating homeostasis by degrading targeted proteins (Latham et al. 2014). The proteasome pathway is closely linked to cell cycle progression and apoptosis, providing a link to cancer. Expression of PSMA1 has been found to be reduced in tissue interstitial fluid in hepatocellular carcinoma compared with normal interstitial fluid of adjacent nontumor tissues (Qin et al. 2017). However, PSMA1 overexpression has been identified in colorectal cancer and breast cancer (Yang et al. 2017).

Target Species: Human
Western Blotting: Mouse anti PSMA1 detects a band of approximately 29 kDa in Jurkat cell lysates
Species Cross-Reactivity: Target Species Cross Reactivity

Mouse

Rat; N.B. Antibody reactivity and working conditions may vary between species.
Product Form: Purified IgG - Liquid
Preparation: Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution: Phosphate buffered saline
Preservative Stabilisers: 0.09% Sodium Azide
Immunogen: E. coli-derived recombinant protein of amino acids 1-263 of human PSMA1
Approx. Protein Concentrations: IgG concentration 1.0 mg/ml
Fusion Partners: Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Regulatory: For research purposes only
Guarantee: 12 months from date of despatch
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories

Target Species	Cross Reactivity
Mouse
Rat

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting			1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Mouse IgG (H/L):HRP	STAR207P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Mouse IgG (H/L):HRP

UniProt: P25786
Entrez Gene: PSMA1
GO Terms: GO:0000082 G1/S transition of mitotic cell cycle; GO:0000084 S phase of mitotic cell cycle; GO:0005515 protein binding; GO:0000216 M/G1 transition of mitotic cell cycle; GO:0003723 RNA binding; GO:0006915 apoptosis; GO:0004298 threonine-type endopeptidase activity; GO:0005634 nucleus; GO:0005737 cytoplasm; View More GO Terms; GO:0005844 polysome; GO:0006521 regulation of cellular amino acid metabolic process; GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; GO:0016032 viral reproduction; GO:0016071 mRNA metabolic process; GO:0042981 regulation of apoptosis; GO:0019773 proteasome core complex, alpha-subunit complex; GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle