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Progesterone Receptor antibody | 1A6

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Anti Human Progesterone Receptor Antibody, clone 1A6 thumbnail image 1 Anti Human Progesterone Receptor Antibody, clone 1A6 thumbnail image 2 Anti Human Progesterone Receptor Antibody, clone 1A6 thumbnail image 3 Anti Human Progesterone Receptor Antibody, clone 1A6 thumbnail image 4 Anti Human Progesterone Receptor Antibody, clone 1A6 thumbnail image 5 Anti Human Progesterone Receptor Antibody, clone 1A6 thumbnail image 6 Anti Human Progesterone Receptor Antibody, clone 1A6 thumbnail image 7
Anti Human Progesterone Receptor Antibody, clone 1A6 gallery image 1
Formalin fixed, paraffin embedded breast cancer biopsy stained with Mouse anti progesterone receptor antibody (MCA1800) followed by the Histar detection system STAR3000B following heat mediated antigen retrieval in citrate buffer pH6.0.
Anti Human Progesterone Receptor Antibody, clone 1A6 gallery image 2
Formalin fixed, paraffin embedded breast cancer biopsy stained with Mouse anti progesterone receptor antibody (MCA1800) followed by the Histar detection system STAR3000B following heat mediated antigen retrieval in citrate buffer pH6.0.
Anti Human Progesterone Receptor Antibody, clone 1A6 gallery image 3
Formalin fixed, paraffin embedded breast cancer biopsy stained with Mouse anti progesterone receptor antibody (MCA1800) followed by the Histar detection system STAR3000B following heat mediated antigen retrieval in citrate buffer pH6.0.
Anti Human Progesterone Receptor Antibody, clone 1A6 gallery image 4
Formalin fixed, paraffin embedded breast cancer biopsy stained with Mouse anti progesterone receptor antibody (MCA1800) followed by the Histar detection system STAR3000B following heat mediated antigen retrieval in citrate buffer pH6.0.
Anti Human Progesterone Receptor Antibody, clone 1A6 gallery image 5
Formalin fixed, paraffin embedded breast cancer biopsy stained with Mouse anti progesterone receptor antibody (MCA1800) followed by the Histar detection system STAR3000B following heat mediated antigen retrieval in citrate buffer pH6.0.
Anti Human Progesterone Receptor Antibody, clone 1A6 gallery image 6
Formalin fixed, paraffin embedded breast cancer biopsy stained with Mouse anti progesterone receptor antibody (MCA1800) followed by the Histar detection system STAR3000B following heat mediated antigen retrieval in citrate buffer pH6.0.
Anti Human Progesterone Receptor Antibody, clone 1A6 gallery image 7
Formalin fixed, paraffin embedded breast cancer biopsy stained with Mouse anti progesterone receptor antibody (MCA1800) followed by the Histar detection system STAR3000B following heat mediated antigen retrieval in citrate buffer pH6.0.

Mouse anti Human Progesterone Receptor

Product Type
Monoclonal Antibody
Clone
1A6
Isotype
IgG1
Product Code Applications Pack Size List Price Quantity
MCA1800
Datasheet
P* WB
SDS
1 ml loader

Mouse anti Human Progesterone Receptor antibody, clone 1A6 recognizes the human progesterone receptor which is a member of the steroid family of nuclear receptors. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

The detection of estrogen (ER) and progesterone (PR) receptors using immunohistochemical staining of formal fixed paraffin embedded (FFPE) tissue, has gradually replaced ligand binding assays (LBA), to become the most common method for the determination of the ER/PR status of breast tumors. Approximately 75% to 80% of breast tumors have estrogen and/or progesterone receptors, and the presence of these receptors helps determine both the patient’s prognosis and the effectiveness of hormonal therapy.

Product Details

Target Species
Human
Product Form
Tissue Culture Supernatant - liquid
Preservative Stabilisers
15mMSodium Azide
Immunogen
Synthetic peptide corresponding to a site of predicted high antigenicity on the human progesterone receptor.
Fusion Partners
Spleen cells from immunized mice were fused with cells of the mouse p3-NS1-Ag4-1 myeloma cell line.

Storage Information

Storage
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Guarantee
Guaranteed until date of expiry. Please see product label.

More Information

UniProt
P06401
Entrez Gene
PGR
GO Terms
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0005102 receptor binding
GO:0005496 steroid binding
GO:0005737 cytoplasm
GO:0005654 nucleoplasm
GO:0007267 cell-cell signaling
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
Regulatory
For research purposes only

Applications of Progesterone Receptor antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 1 1/40
Western Blotting 1/25 1/50
  1. 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
Uterus
Copyright © 2021 Bio-Rad Antibodies (formerly AbD Serotec)

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Mouse IgG (H/L):Alk. Phos. (Multi Species Adsorbed) STAR117A E WB 0.5 mg loader
Goat anti Mouse IgG (H/L):DyLight®488 (Multi Species Adsorbed) STAR117D488GA F IF 0.1 mg loader
Goat anti Mouse IgG (H/L):DyLight®680 (Multi Species Adsorbed) STAR117D680GA F WB 0.1 mg loader
Goat anti Mouse IgG (H/L):DyLight®800 (Multi Species Adsorbed) STAR117D800GA F IF WB 0.1 mg loader
Goat anti Mouse IgG (H/L):FITC (Multi Species Adsorbed) STAR117F F 0.5 mg loader
Goat anti Mouse IgG (H/L):HRP (Multi Species Adsorbed) STAR117P E WB 0.5 mg loader
Goat anti Mouse IgG (Fc):FITC STAR120F C F 1 mg loader
Goat anti Mouse IgG (Fc):HRP STAR120P E WB 1 mg loader
Rabbit F(ab')2 anti Mouse IgG:RPE STAR12A F 1 ml loader
Goat anti Mouse IgG:FITC (Rat Adsorbed) STAR70 F 0.5 mg loader
Goat anti Mouse IgG:RPE (Rat Adsorbed) STAR76 F 1 ml loader
Goat anti Mouse IgG:HRP (Rat Adsorbed) STAR77 C E P 0.5 mg loader
Goat anti Mouse IgG/A/M:Alk. Phos. STAR87A C E WB 1 mg loader
Goat anti Mouse IgG/A/M:HRP (Human Adsorbed) STAR87P E 1 mg loader
Rabbit F(ab')2 anti Mouse IgG:Dylight®800 STAR8D800GA F IF WB 0.1 mg loader
Rabbit F(ab')2 anti Mouse IgG:FITC STAR9B F 1 mg loader
Rabbit F(ab')2 anti Mouse IgG:HRP (Human Adsorbed) STAR13B C E P RE WB 1 mg loader

Product Specific References

References for Progesterone Receptor antibody

  1. Ambroise, M. et al. (2011) Immunohistochemical profile of breast cancer patients at a tertiary care hospital in South India.
    Asian Pac J Cancer Prev. 12: 625-9.
  2. Krishnaswamy, U. et al. (2013) Correlation of Her-2 neu over-expression with clinico pathological features of carcinoma breast
    Apollo Medicine. 10 (4): 313-7.

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