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PI-3 Kinase Subunit Gamma antibody | OTI6D1

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Anti PI-3 Kinase Subunit Gamma Antibody, clone OTI6D1 (PrecisionAb Monoclonal Antibody) thumbnail image 1 Anti PI-3 Kinase Subunit Gamma Antibody, clone OTI6D1 (PrecisionAb Monoclonal Antibody) thumbnail image 2
Anti PI-3 Kinase Subunit Gamma Antibody, clone OTI6D1 (PrecisionAb Monoclonal Antibody) gallery image 1
Western blot analysis of PI-3 kinase subunit gamma expression in K562 whole cell lysate probed with Mouse anti PI-3 Kinase Subunit Gamma antibody (VMA00277) followed by detection with HRP conjugated Goat anti Mouse IgG (1/10,000 STAR207P) and visualized on the ChemiDoc MP with a 300 second exposure. Arrow points at PI-3 kinase subunit gamma.
Anti PI-3 Kinase Subunit Gamma Antibody, clone OTI6D1 (PrecisionAb Monoclonal Antibody) gallery image 2
Western blot analysis of PI-3 kinase subunit gamma expression in Jurkat whole cell lysate probed with Mouse anti PI-3 Kinase Subunit Gamma antibody (VMA00277) followed by detection with HRP conjugated Goat anti Mouse IgG (1/10,000 STAR207P) and visualized on the ChemiDoc MP with a 60 second exposure. Arrow points at PI-3 kinase subunit gamma.

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WB

Mouse anti PI-3 Kinase Subunit Gamma

Product Type
PrecisionAb Monoclonal
Clone
OTI6D1
Isotype
IgG2a
Format
Purified
Specificity
PI-3 Kinase Subunit Gamma

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Technical Suppport
Product Code Applications Pack Size List Price Your Price Qty
VMA00277
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SDS Safety Datasheet SDS
WB 100 µl loader
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Mouse anti Human PI-3 kinase subunit gamma antibody recognizes the phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, also known as 1-phosphatidylinositol 3-kinase, phosphatidylinositol 3 kinase gamma, p110 gamma, phosphatidylinositol 3-kinase catalytic 110-kD gamma, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, phosphoinositide-3-kinase gamma catalytic subunit, ptdIns-3-kinase subunit gamma, ptdIns-3-kinase subunit p110-gamma and serine/threonine protein kinase PIK3CG.

A product of the PIK3CG gene, PI-3 kinase subunit gamma belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for PIK3CG (provided by RefSeq, Sep 2013).

Mouse anti Human PI-3 kinase subunit gamma isoform antibody detects a band of 126 kDa. The antibody has been extensively validated for western blotting using whole cell lysates. 		PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti PI-3 Kinase subunit gamma detects a band of approximately 126 kDa in K562 cell lysates.
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody purified by affinity chromatography from ascites.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
50% Glycerol
Immunogen
Full length recombinant human PI-3 kinase subunit gamma (NP_002640) produced in HEK293T cells
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description Product Code Applications Pack Size List Price Your Price Quantity
Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml loader
List Price Your Price
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Description Goat anti Mouse IgG (H/L):HRP

UniProt
P48736
Entrez Gene
PIK3CG
GO Terms
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0007186 G-protein coupled receptor protein signaling pathway
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0048015 phosphatidylinositol-mediated signaling
GO:0030168 platelet activation
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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