PGRMC1 antibody | CD02/1A2

Mouse anti PGRMC1

Product Type
PrecisionAb Monoclonal
Clone
CD02/1A2
Isotype
IgG1
Format
Purified
Specificity
PGRMC1

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VMA00943
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 100 µl loader
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Mouse anti PGRMC1 antibody recognizes membrane-associated progesterone receptor component 1, also known as mPR, Dap1 and IZA. PGRMC1 is a component of the membrane associated progesterone receptor (MAPR) and has a wide range of functions including vesicle trafficking, regulation of sterol synthesis, regulation of entry into the G0 stage of the cell cycle, invasive growth, and hypoxic biology (Cahill 2017). PGRMC1 has been shown to localize at various subcellular compartments including endoplasmic reticulum, Golgi apparatus, plasma membrane, inner acrosomal membrane, nucleus, nucleolus, and mitochondria (Kim et al. 2019). PGRMC1 appears to be involved with cancers, particularly those of the female reproductive tract, and with central nervous system disorders, such as Alzheimer's Disease (Cahill et al. 2016). PGRMC1 represents a marker of proliferation for many types of cancer cell. PrecisionAb Antibodies

Target Species
Human
Western Blotting
Mouse anti PGRMC1 detects a band of approximately 24 kDa in HepG2 cell lysates
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - Liquid
Preparation
Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
Immunogen
E. coli-derived recombinant protein of amino acids 44-195 of human PGRMC1
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Regulatory
For research purposes only
Guarantee
12 months from date of despatch
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml loader
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Description Goat anti Mouse IgG (H/L):HRP

UniProt
O00264
Entrez Gene
PGRMC1
GO Terms
GO:0005515 protein binding
GO:0016021 integral to membrane
GO:0004872 receptor activity
GO:0005496 steroid binding
GO:0005730 nucleolus
GO:0005789 endoplasmic reticulum membrane
GO:0005792 microsome
GO:0009986 cell surface
GO:0020037 heme binding
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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