PAX2 antibody | 3C7

Mouse anti Human PAX2:Preservative Free

Product Type
Monoclonal Antibody
Clone
3C7
Isotype
IgG2a
Specificity
PAX2

Product Code Applications Pack Size List Price Your Price Qty
MCA4953Z
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
P 0.1 mg loader
List Price Your Price
loader
Search for Batch Specific Datasheets

Mouse anti Human PAX2 antibody, clone 3C7 recognizes human Paired box protein Pax-2. Pax-2 is a 417 amino acid ~45 kDa nuclear protein critical to the development of the urinogential tract, eyes and CNS (Eccles et al. 2002).

Mutations in the PAX2 gene can lead to deveolpment of Papillorenal syndrome (PAPRS) demonstrating both renal and ocular problems (Salomon et al. 2001, Higashide et al. 2005) or Focal segmental glomerulosclerosis 7 (FSGS7) showing segmental sclerosis of glomeruli (Barua et al. 2014).

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A from ascites
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
None present
Immunogen
Recombinant protein corresponding to aa 194 - 304 of human PAX2.
Approx. Protein Concentrations
Ig concentration 0.5 mg/ml
Fusion Partners
Spleen cells from BALB/c mice were fused with cells from the Sp2/0 myeloma cell line.
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunohistology - Paraffin 0.1 10 ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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Description Goat anti Mouse IgG (H/L):HRP (Multi Species Adsorbed)
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Description Goat anti Mouse IgG (H/L):DyLight®488 (Multi Species Adsorbed)
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Description Goat anti Mouse IgG (H/L):DyLight®680 (Multi Species Adsorbed)
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Description Goat anti Mouse IgG (H/L):DyLight®800 (Multi Species Adsorbed)
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Description Goat anti Mouse IgG (H/L):DyLight®650 (Multi Species Adsorbed)
Goat anti Mouse IgG (H/L):DyLight®550 (Multi Species Adsorbed) STAR117D550 F IF WB 0.1 mg loader
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Description Goat anti Mouse IgG (H/L):DyLight®550 (Multi Species Adsorbed)

References for PAX2 antibody

  1. Markowska, A. et al. (2013) Does Metformin affect ER, PR, IGF-1R, β-catenin and PAX-2 expression in women with diabetes mellitus and endometrial cancer?
    Diabetol Metab Syndr. 5 (1): 76.

RRID
AB_2299197
UniProt
Q02962
Entrez Gene
PAX2
GO Terms
GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0005634 nucleus
GO:0006366 transcription from RNA polymerase II promoter
GO:0007409 axonogenesis
GO:0007601 visual perception
GO:0010843 promoter binding
GO:0016563 transcription activator activity
GO:0034451 centriolar satellite
GO:0072162 metanephric mesenchymal cell differentiation
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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