PAX2 antibody | 3C7
Mouse anti Human PAX2 antibody, clone 3C7 (MCA4953Z) used to stain post-menopausal endometrial cancer specimens by immunohistochemistry on formalin fixed, paraffin embedded tissue samples.
Image caption:
Nuclear immunostaining for nuclear PAX-2 (A) and IGF-1R membranous type of staining (B).
From: Markowska A, Pawałowska M, Filas V, Korski K, Gryboś M, Sajdak S, Olejek A, Bednarek W, Spiewankiewicz B, Lubin J, Markowska J.
Does Metformin affect ER, PR, IGF-1R, β-catenin and PAX-2 expression in women with diabetes mellitus and endometrial cancer?
Diabetol Metab Syndr. 2013 Dec 5;5(1):76.
doi: 10.1186/1758-5996-5-76.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Filter by Application:
P ResetMouse anti Human PAX2:Preservative Free
- Product Type
- Monoclonal Antibody
- Clone
- 3C7
- Isotype
- IgG2a
- Specificity
- PAX2
Antibody Quality and Performance Guarantee
| Mouse anti Human PAX2 antibody, clone 3C7 recognizes human Paired box protein Pax-2. Pax-2 is a 417 amino acid ~45 kDa nuclear protein critical to the development of the urinogential tract, eyes and CNS (Eccles et al. 2002). Mutations in the PAX2 gene can lead to deveolpment of Papillorenal syndrome (PAPRS) demonstrating both renal and ocular problems (Salomon et al. 2001, Higashide et al. 2005) or Focal segmental glomerulosclerosis 7 (FSGS7) showing segmental sclerosis of glomeruli (Barua et al. 2014). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from ascites
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Immunogen
- Recombinant protein corresponding to aa 194 - 304 of human PAX2.
- Approx. Protein Concentrations
- Ig concentration 0.5 mg/ml
- Fusion Partners
- Spleen cells from BALB/c mice were fused with cells from the Sp2/0 myeloma cell line.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunohistology - Paraffin |  |
0.1 | 10 ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
References for PAX2 antibody
-
Markowska, A. et al. (2013) Does Metformin affect ER, PR, IGF-1R, β-catenin and PAX-2 expression in women with diabetes mellitus and endometrial cancer?
Diabetol Metab Syndr. 5 (1): 76.
- RRID
- AB_2299197
- UniProt
- Q02962
- Entrez Gene
- PAX2
- GO Terms
- GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis
- GO:0005634 nucleus
- GO:0006366 transcription from RNA polymerase II promoter
- GO:0007409 axonogenesis
- GO:0007601 visual perception
- GO:0010843 promoter binding
- GO:0016563 transcription activator activity
- GO:0034451 centriolar satellite
- GO:0072162 metanephric mesenchymal cell differentiation
- View More GO Terms
MCA4953Z
160830
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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