p70S6K antibody | 1E12




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WB IF P ResetMouse anti Human p70S6K:Preservative Free
- Product Type
- Monoclonal Antibody
- Clone
- 1E12
- Isotype
- IgG2b
- Specificity
- p70S6K
Mouse anti Human p70S6K antibody, clone 1E12 recognizes human p70S6K, also known as Ribosomal protein S6 kinase beta-1, 70 kDa ribosomal protein S6 kinase 1, Ribosomal protein S6 kinase I, Serine/threonine-protein kinase 14A or p70 ribosomal S6 kinase alpha. p70S6K is a 525 amino acid ~70 kDa Serine/threonine-protein kinase acting to promote cell division and survival through inhibition of pro-apoptotic activity of (BAD). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from ascites
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Immunogen
- Recombinant protein corresponding to aa 416 - 526 of human p70S6K encoded by gene RPS6KB1.
- Approx. Protein Concentrations
- Ig concentration 0.5 mg/ml
- Fusion Partners
- Spleen cells from BALB/c mice were fused with cells from the Sp2/0 myeloma cell line.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Immunofluorescence | ![]() |
0.1 | 10 ug/ml |
Immunohistology - Paraffin 1 | ![]() |
0.1 | 10 ug/ml |
Western Blotting | ![]() |
- 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.
References for p70S6K antibody
-
Bodnar, L. et al. (2015) Clinical usefulness of PI3K/Akt/mTOR genotyping in companion with other clinical variables in metastatic renal cell carcinoma patients treated with everolimus in the second and subsequent lines.
Ann Oncol. 26 (7): 1385-9.
- Synonyms
- RPS6KB1
- RRID
- AB_2182100
- UniProt
- P23443
- Entrez Gene
- RPS6KB1
- GO Terms
- GO:0000082 G1/S transition of mitotic cell cycle
- GO:0005515 protein binding
- GO:0006915 apoptosis
- GO:0005829 cytosol
- GO:0004672 protein kinase activity
- GO:0005524 ATP binding
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005741 mitochondrial outer membrane
- View More GO Terms
- GO:0008286 insulin receptor signaling pathway
- GO:0019717 synaptosome
- GO:0048015 phosphatidylinositol-mediated signaling
- GO:0030054 cell junction
- GO:0031929 TOR signaling cascade
- GO:0043066 negative regulation of apoptosis
- GO:0045202 synapse
- GO:0045931 positive regulation of mitotic cell cycle
- GO:0045948 positive regulation of translational initiation
MCA3430Z


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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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