Mouse anti Human p15 antibody, clone DCS-114.1 recognises human p15-Ink4b, also known as Cyclin-dependent kinase 4 inhibitor B or Multiple tumor suppressor 2. p15-Ink4b is a 138 amino acid, ~15 kDa cytoplasmic tumor suppressor protein which inhibits the cyclin D dependent kinases cdk4/6.
- Target Species
- Product Form
- Purified IgG - liquid
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- Full length recombinant p15 His tagged.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
regulation of cyclin-dependent protein kinase activity
G1 phase of mitotic cell cycle
G2/M transition of mitotic cell cycle
cyclin-dependent protein kinase inhibitor activity
cell cycle arrest
protein kinase binding
positive regulation of transforming growth factor beta receptor signaling pathway
mitotic cell cycle G1/S transition checkpoint
cellular response to nutrient
negative regulation of epithelial cell proliferation
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of p15 antibody
|Immunohistology - Frozen
- 1 N.B. Clone DCS114.1 co-precipitates cdk4/cdk6.
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
Application Based External Images
Product Specific References
References for p15 antibody
Yoon, G. et al. (2002) Iron chelation-induced senescence-like growth arrest in hepatocyte cell lines: association of transforming growth factor beta1 (TGF-beta1)-mediated p27Kip1 expression.
Biochem J. 366 (Pt 2): 613-21.
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