Osteoprotegerin antibody
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WB ResetMouse anti Osteoprotegerin
- Product Type
- PrecisionAb Monoclonal
- Isotype
- IgG1
- Format
- Purified
- Specificity
- Osteoprotegerin
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| Mouse anti Human osteoprotegerin antibody recognizes the tumor necrosis factor receptor superfamily member 11B , also known as osteoclastogenesis inhibitory factor or OPG. The protein encoded by TNFRSF11B is a member of the TNF-receptor superfamily. Osteoprotegerin is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein binds to its ligand, osteoprotegerin ligand, and both are key extracellular regulators of osteoclast development. The mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of TNFRSF11B have been reported (provided by RefSeq, Jul 2008). Mouse anti Human osteoprotegerin antibody detects a band of 60 kDa. The antibody has been extensively validated for western blotting using whole cell lysates. |
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- Target Species
- Human
- Western Blotting
- Anti osteoprotegerin detects a band of approximately 60 kDa in Jurkat cell lysates.
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from ascites.
- Buffer Solution
- Phosphate buffered saline.
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3).
- Immunogen
- E. coli derived recombinant protein corresponding to aa 22-201 of human osteoprotegerin
- Regulatory
- For research purposes only.
- Guarantee
- 12 months from date of despatch.
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories.
Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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| List Price | Your Price | ||||||
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| Description | Goat anti Mouse IgG (H/L):HRP | ||||||
- UniProt
- O00300
- Entrez Gene
- TNFRSF11B
- GO Terms
- GO:0001501 skeletal system development
- GO:0006915 apoptosis
- GO:0004872 receptor activity
- GO:0005125 cytokine activity
View more products with Osteoprotegerin specificity
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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