NR2C2 antibody | OTI1E1

Mouse anti NR2C2

Product Type
PrecisionAb Monoclonal
Clone
OTI1E1
Isotype
IgG2a
Format
Purified
Specificity
NR2C2

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VMA00214
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WB 100 µl loader
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Mouse anti Human NR2C2 antibody, clone OTI1E1 recognizes the nuclear receptor subfamily 2 group C member 2, also known as nuclear hormone receptor TR4, nuclear receptor subfamily 2 group C member 2, orphan nuclear receptor TAK1, orphan nuclear receptor TR4 and testicular nuclear receptor 4.

Members of the nuclear hormone receptor family, such as NR2C2, act as ligand-activated transcription factors. The proteins have an N-terminal transactivation domain, a central DNA-binding domain with 2 zinc fingers, and a ligand-binding domain at the C terminus. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes (Yoshikawa et al. 1996).

Mouse anti Human NR2C2 antibody, clone OTI1E1 detects a band of 67 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti NR2C2 detects a band of approximately 67 kDa in Jurkat cell lysates.
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody purified by affinity chromatography from ascites.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
50% Glycerol
Immunogen
Recombinant protein corresponding to amino acids 1-241 of human NR2C2 (NP_003289) produced in E. coli
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Description Goat anti Mouse IgG (H/L):HRP

UniProt
P49116
Entrez Gene
NR2C2
GO Terms
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0003713 transcription coactivator activity
GO:0005654 nucleoplasm
GO:0007283 spermatogenesis
GO:0007399 nervous system development
GO:0008270 zinc ion binding
GO:0030154 cell differentiation
GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
GO:0043565 sequence-specific DNA binding
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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