NOB1 antibody | F02/5F11

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WB ResetMouse anti NOB1
- Product Type
- PrecisionAb Monoclonal
- Clone
- F02/5F11
- Isotype
- IgG1
- Format
- Purified
- Specificity
- NOB1
Mouse anti NOB1 antibody recognizes RNA-binding protein NOB1, also known as ART4, NOB1P, and PSMD8BP1. NOB1 is a component of the 26S proteasome and plays an important role in protease function and RNA metabolism (Liu et al. 2015). It acts as a chaperone, joining the 20S proteasome with 19S regulatory particle in the nucleus and facilitating maturation of the 20S proteasome. NOB1 has been suggested to play a role in cell cycle progression, drug resistance and tumorigenesis (Li et al. 2013). Abnormal NOB1 expression may lead to dysfunctions in protein synthesis and protein degradation. Given that rapidly growing cancer cells have a high requirement for protein, dysregulation of NOB1 can be involved with cancer. Accordingly, many roles have been found for NOB1 in the development of cancer (Luo et al. 2018). NOB1 expression is upregulated in a variety of malignancies including prostate carcinoma, thyroid cancer, breast infiltrating ductal carcinoma and non-small lung cancer (Lin et al. 2015). |
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- Target Species
- Human
- Western Blotting
- Mouse anti NOB1 detects a band of approximately 49 kDa in HEK293 cell lysates
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - Liquid
- Preparation
- Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- Immunogen
- E. coli-derived recombinant protein of amino acids 1-412 of human NOB1
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Western Blotting | ![]() |
1/10000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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List Price | Your Price | ||||||
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Description | Goat anti Mouse IgG (H/L):HRP |
- UniProt
- Q9ULX3
- Entrez Gene
- NOB1
- GO Terms
- GO:0005515 protein binding
- GO:0046872 metal ion binding
- GO:0005634 nucleus
VMA00946

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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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