Neurofilament antibody | OTI3G2
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WB ResetMouse anti Neurofilament
- Product Type
- PrecisionAb Monoclonal
- Clone
- OTI3G2
- Isotype
- IgG1
- Format
- Purified
- Specificity
- Neurofilament
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| Mouse anti Human neurofilament antibody, clone OTI3G2 recognizes neurofilament, also known as light molecular weight neurofilament protein, neurofilament light polypeptide, neurofilament protein, light chain, neurofilament subunit NF-L, neurofilament triplet L protein, neurofilament, light polypeptide 68kDa and protein phosphatase 1 regulatory subunit 110. Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. The NEFL gene encodes the light chain neurofilament protein. Mutations in NEFL cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y (provided by RefSeq, Oct 2008). Mouse anti Human neurofilament antibody, clone OTI3G2 detects a band of 70 kDa. The antibody has been extensively validated for western blotting using whole cell lysates. |
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- Target Species
- Human
- Western Blotting
- Anti neurofilament detects a band of approximately 70 kDa in mouse brain cell lysates.
- Species Cross-Reactivity
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Target Species Cross Reactivity Mouse - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Mouse monoclonal antibody purified by affinity chromatography from ascites.
- Buffer Solution
- Phosphate buffered saline.
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
50% Glycerol - Immunogen
- Recombinant protein fragment corresponding to amino acids 1-360 of human neurofilament (NP_006149) produced in E. coli
- Regulatory
- For research purposes only.
- Guarantee
- 12 months from date of despatch.
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories.
Store undiluted at -20°C, avoiding repeated freeze thaw cycles.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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| Description | Goat anti Mouse IgG (H/L):HRP | ||||||
- UniProt
- P07196
- Entrez Gene
- NEFL
- GO Terms
- GO:0005829 cytosol
- GO:0005200 structural constituent of cytoskeleton
- GO:0005883 neurofilament
- GO:0007268 synaptic transmission
- GO:0008022 protein C-terminus binding
- GO:0008089 anterograde axon cargo transport
- GO:0008090 retrograde axon cargo transport
- GO:0042802 identical protein binding
- GO:0019896 axon transport of mitochondrion
- View More GO Terms
- GO:0033693 neurofilament bundle assembly
View more products with NEUROFILAMENT specificity
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