NDRG1 antibody | GH01/4A7

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Mouse anti NDRG1

Product Type
PrecisionAb Monoclonal
Clone
GH01/4A7
Isotype
IgG1
Format
Purified
Product Code Applications Pack Size List Price Quantity
VMA00950
Datasheet
WB
SDS
100 µl loader

Mouse anti NDRG1 antibody recognizes protein NDRG1, also known as DRG-1 and RTP. NDRG1 is a stress-response protein induced by hypoxia and cell differentiation signals. It has been found to act as a tumor suppressor in a variety of cancer types, suppressing migration, invasion, and metastasis by regulating epithelial-mesenchymal transition (EMT) or downregulating ErbB receptors (Dong et al. 2019). However, NDRG1 may have an oncogenic role in other cancerous conditions, making its role in cancer more complex (Du et al. 2018). For example, overexpression of NDRG1 has been found to be associated with elevated rates of metastasis and mortality in patients with breast cancer (Sevinsky et al. 2018).

Product Details

Target Species
Human
Western Blotting
Mouse anti NDRG1 detects a band of approximately 45 kDa in HT-1080 cell lysates
Product Form
Purified IgG - Liquid
Preparation
Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide
Immunogen
E. coli-derived recombinant protein of amino acids 1-394 of human NDRG1
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line

Storage Information

Storage
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
Guarantee
12 months from date of despatch

More Information

UniProt
Q92597
Entrez Gene
NDRG1
GO Terms
GO:0005886 plasma membrane
GO:0005515 protein binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0010038 response to metal ion
GO:0015630 microtubule cytoskeleton
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories
Regulatory
For research purposes only

Applications of NDRG1 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Secondary Antibodies Available

Description Product Code Applications Pack Size List Price Quantity
Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml

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