NBS1 antibody | AB02/3A3

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Anti NBS1 Antibody, clone AB02/3A3 (PrecisionAb Monoclonal Antibody) thumbnail image 1

Anti NBS1 Antibody, clone AB02/3A3 (PrecisionAb Monoclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with NBS1 antibody followed by detection with HRP conjugated Goat anti Mouse IgG (1/10,000, STAR207P) and visualized on the ChemiDoc MP with 37 second exposure. Arrow points to NBS1 (molecular weight 95 kDa)

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Mouse anti NBS1

Product Type: PrecisionAb Monoclonal
Clone: AB02/3A3
Isotype: IgG1
Format: Purified
Specificity: NBS1

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VMA00524 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Mouse anti Human NBS1 antibody recognizes nibrin, also known as ATV, NBN or p95.

Mutations in the NBS1 gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. NBS1 is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation (provided by RefSeq, Jul 2008)

Mouse anti Human NBS1 antibody detects a band of 95 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

Target Species: Human
Western Blotting: Anti NBS1 detects a band of approximately 95 kDa in K562 cell lysates.
Species Cross-Reactivity: Target Species Cross Reactivity

Rat; N.B. Antibody reactivity and working conditions may vary between species.
Product Form: Purified IgG - liquid
Preparation: Mouse monoclonal antibody purified by affinity chromatography on Protein G from tissue culture supernatant.
Buffer Solution: Phosphate buffered saline.
Preservative Stabilisers: 0.09% Sodium Azide (NaN₃).
Immunogen: E. coli-derived recombinant human NBS1 (amino acids 461 - 754)
Regulatory: For research purposes only.
Guarantee: 12 months from date of despatch.
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories.

Target Species	Cross Reactivity
Rat

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Mouse IgG (H/L):HRP	STAR207P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Mouse IgG (H/L):HRP

UniProt: O60934
Entrez Gene: NBN
GO Terms: GO:0000723 telomere maintenance; GO:0000724 double-strand break repair via homologous recombination; GO:0000784 nuclear chromosome, telomeric region; GO:0005654 nucleoplasm; GO:0005730 nucleolus; GO:0007050 cell cycle arrest; GO:0007095 mitotic cell cycle G2/M transition DNA damage checkpoint; GO:0007126 meiosis; GO:0008134 transcription factor binding; View More GO Terms; GO:0030174 regulation of DNA-dependent DNA replication initiation; GO:0030330 DNA damage response, signal transduction by p53 class mediator; GO:0030870 Mre11 complex; GO:0031575 mitotic cell cycle G1/S transition checkpoint; GO:0031954 positive regulation of protein autophosphorylation; GO:0032508 DNA duplex unwinding; GO:0033674 positive regulation of kinase activity; GO:0042405 nuclear inclusion body; GO:0047485 protein N-terminus binding