N-Cadherin antibody | OTI2G7
KO Validated
Mouse anti Human N-cadherin antibody recognizes N-cadherin, also known as N-cadherin 1, cadherin 2, calcium-dependent adhesion protein neuronal and neural cadherin.
N-cadherin is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by CDH2 product (provided by RefSeq, Jul 2008).
Mouse anti Human N-cadherin antibody detects a band of 140 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
N-cadherin is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by CDH2 product (provided by RefSeq, Jul 2008).
Mouse anti Human N-cadherin antibody detects a band of 140 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
Product Details
- Target Species
- Human
- Western Blotting
- Mouse anti N-cadherin antibody detects a band of approximately 140 kDa in C6 cell lysates
- Species Cross-Reactivity
-
Target Species Cross Reactivity Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Mouse monoclonal antibody purified by affinity chromatograpy on Protein A from ascites
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
<50% Glycerol - Immunogen
- HEK293-derived full length recombinant human N-cadherin
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
Storage Information
- Storage
- Store undiluted at -20oC, avoiding repeated freeze thaw cycles
- Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P19022
- Entrez Gene
- CDH2
- GO Terms
- GO:0005509 calcium ion binding
- GO:0016021 integral to membrane
- GO:0008013 beta-catenin binding
- GO:0016342 catenin complex
- GO:0034329 cell junction assembly
- GO:0034332 adherens junction organization
- GO:0042692 muscle cell differentiation
- GO:0045294 alpha-catenin binding
- GO:0045295 gamma-catenin binding
- GO:0051149 positive regulation of muscle cell differentiation
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories.
- Regulatory
- For research purposes only
Applications of N-Cadherin antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
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Secondary Antibodies Available
| Description | Product Code | Applications | Pack Size | List Price | Quantity |
|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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