MyD88 antibody | KL01/3A2

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Anti MyD88 Antibody, clone KL01/3A2 (PrecisionAb Monoclonal Antibody) thumbnail image 1

Anti MyD88 Antibody, clone KL01/3A2 (PrecisionAb Monoclonal Antibody) thumbnail image 2

Anti MyD88 Antibody, clone KL01/3A2 (PrecisionAb Monoclonal Antibody) gallery image 1 — Western blot analysis of whole cell lysates probed with MyD88 antibody (1/1000, **VMA00945**) followed by detection with HRP conjugated Goat anti Mouse IgG (1/10000, STAR207P) and visualized on the ChemiDoc MP.

Anti MyD88 Antibody, clone KL01/3A2 (PrecisionAb Monoclonal Antibody) gallery image 2 — Western blot analysis of whole cell lysates probed with MyD88 antibody (1/500, **VMA00945**) followed by detection with HRP conjugated Goat anti Mouse IgG (1/10000, STAR207P) and visualized on the ChemiDoc MP. Arrow points to MyD88 (molecular weight 36 kDa)

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Mouse anti MyD88

Product Type: PrecisionAb Monoclonal
Clone: KL01/3A2
Isotype: IgG2a
Format: Purified
Specificity: MyD88

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Product Code Applications Pack Size List Price Your Price Qty

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VMA00945 Datasheet Datasheet SDS SDS	WB	100 µl		Log in	Get Quote
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Mouse anti MyD88 antibody recognizes myeloid differentiation primary response protein MyD88. MyD88 is the primary mediator of inflammatory pathways downstream of the Toll-like receptor (TLR) and interleukin-1 (IL-1) receptor families, achieving these functions by activating IRAK family kinases. Accordingly, MyD88 plays an important role in innate immune signaling (Deguine and Barton 2014). MyD88 is also able to modulate energy, glucose, and lipid metabolism, acting as a nutrient sensor in the intestinal epithelium and controlling energy expenditure (Lefort et al. 2019). A role in immune response to allergens has also been identified for MyD88 (Thomas et al. 2018). Disruption of the gene encoding MyD88 has been found to suppress a range of tumor types in mice. Accordingly, it has been suggested that signaling through MyD88 promotes tumorigenesis (Echizen et al. 2016). Consistent with this, mutations in the gene encoding MyD88 leads to cancer development (Hindi et al. 2017).

Target Species: Human
Western Blotting: Mouse anti MyD88 detects a band of approximately 36 kDa in Jurkat cell lysates
Product Form: Purified IgG - Liquid
Preparation: Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
Buffer Solution: Phosphate buffered saline
Preservative Stabilisers: 0.09% Sodium Azide
Immunogen: E. coli-derived recombinant protein of amino acids 1-296 of human MyD88
Approx. Protein Concentrations: IgG concentration 1.0 mg/ml
Fusion Partners: Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Regulatory: For research purposes only
Guarantee: 12 months from date of despatch
Acknowledgements: PrecisionAb is a trademark of Bio-Rad Laboratories

Store undiluted at -20°C, avoiding repeated freeze thaw cycles

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
Western Blotting		1/500	1/1000

The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

Description	Product Code	Applications	Pack Size	Your Price
Goat anti Mouse IgG (H/L):HRP	STAR207P	WB	2 ml	Log in	Get Quote
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Description	Goat anti Mouse IgG (H/L):HRP

UniProt: Q99836
Entrez Gene: MYD88
GO Terms: GO:0005886 plasma membrane; GO:0002755 MyD88-dependent toll-like receptor signaling pathway; GO:0005829 cytosol; GO:0004888 transmembrane receptor activity; GO:0005123 death receptor binding; GO:0006916 anti-apoptosis; GO:0006954 inflammatory response; GO:0008063 Toll signaling pathway; GO:0010008 endosome membrane; View More GO Terms; GO:0031224 intrinsic to membrane; GO:0032740 positive regulation of interleukin-17 production; GO:0032747 positive regulation of interleukin-23 production; GO:0032755 positive regulation of interleukin-6 production; GO:0034130 toll-like receptor 1 signaling pathway; GO:0034134 toll-like receptor 2 signaling pathway; GO:0034142 toll-like receptor 4 signaling pathway; GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade; GO:0045087 innate immune response; GO:0048011 nerve growth factor receptor signaling pathway; GO:0050727 regulation of inflammatory response; GO:0070555 response to interleukin-1