MEK 6 antibody

Mouse anti MEK 6

Product Type
PrecisionAb Monoclonal
Isotype
IgG1
Format
Purified
Specificity
MEK 6

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VMA00672
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Mouse anti Human MEK 6 antibody recognizes the dual specificity mitogen-activated protein kinase kinase 6, also known as MAPK/ERK kinase 6, MAPKK 6, SAPK kinase 3 or stress-activated protein kinase kinase 3.

The MAP2K6 gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, MEK 6 is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis (provided by RefSeq, Jul 2008).

Mouse anti MEK 6 antibody detects a band of 38 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Mouse anti MEK 6 antibody detects a band of approximately 38 kDa in Jurkat cell lysates.
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody purified by affinity chromatograpy from ascites.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
E coli-derived recombinant protein of partial human MEK 6
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Goat anti Mouse IgG (H/L):HRP STAR207P WB 2 ml loader
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Description Goat anti Mouse IgG (H/L):HRP

UniProt
P52564
Entrez Gene
MAP2K6
GO Terms
GO:0000187 activation of MAPK activity
GO:0005515 protein binding
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0005829 cytosol
GO:0004674 protein serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0006975 DNA damage induced protein phosphorylation
GO:0007050 cell cycle arrest
GO:0008063 Toll signaling pathway
GO:0034130 toll-like receptor 1 signaling pathway
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0042692 muscle cell differentiation
GO:0045087 innate immune response
GO:0051149 positive regulation of muscle cell differentiation
GO:0051403 stress-activated MAPK cascade
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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