Mouse anti MBP (pThr98) antibody, clone 98P/12
recognizes myelin basic protein (MBP), also known as myelin A1 protein and myelin membrane encephalitogenic protein, when phosphorylated at threonine 98. The numbering of the threonine residue refers to UniProt entry : P02686-5
. Myelin basic protein Isoform 5, a truncated form of MBP lacking the N-terminal residues. The equivalent threonine in the canonical isoform 1 is thr232.
- Target Species
- Product Form
- Purified IgG - liquid
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- Synthetic peptide from human myelin basic protein sequence, phosphorylated on threonine 98 with the sequence FFKNIVTPR(pT)PPPSQGK.
- Approx. Protein Concentrations
- IgG concentration 1 mg/ml
- This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
- 12 months from date of despatch
- Entrez Gene
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of MBP (pThr98) antibody
|Immunohistology - Frozen
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available
Product Specific References
References for MBP (pThr98) antibody
Yon, M. et al. (1995) Preparation of a novel monoclonal antibody specific for myelin basic protein phosphorylated on Thr98.
J Neuroimmunol. 58 (2): 121-9.
Yon, M. et al. (1996) Identification of a mitogen-activated protein kinase site in human myelin basic protein in situ.
J Neuroimmunol. 65 (1): 55-9.
DeBruin, L.S. et al. (2005) Developmental partitioning of myelin basic protein into membrane microdomains.
J Neurosci Res. 80: 211-25.
DeBruin, L.S. et al. (2006) Partitioning of myelin basic protein into membrane microdomains in a spontaneously demyelinating mouse model for multiple sclerosis.
Biochem Cell Biol. 84: 993-1005.
Boggs, J.M. and Wang, H. (2004) Co-clustering of galactosylceramide and membrane proteins in oligodendrocyte membranes on interaction with polyvalent carbohydrate and prevention by an intact cytoskeleton.
J Neurosci Res. 76: 342-55.
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