MALT1 antibody | 50
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|Mouse anti Human MALT1 antibody, clone 50 recognizes human mucosal-associated lymphoid tissue lymphoma translocation 1 (MALT1), also known as MALT lymphoma-associated translocation and paracaspase. MALT1 is an 824 amino acid ~93 kDa protein belonging to the peptidase C14B family containing a single death domain and two Ig-like CD-type domains. In normal lymphocytes, MALT1 plays an important role in antigen receptor-mediated lymphocyte activation. In T-cells, MALT1 is recruited by activated CARMA1, along with Bcl-10, to form a CARMA1-Bcl10-MALT1 (CBM) complex which is involved in the activation of NF-kappaB (Yang et al. 2013).
MALT1 was initially identified as a recurrent translocation t(11;18)(q21:q21) in mucosal-associated lymphomas (Horsman et al. 1992), which creates a functional fusion oncoprotein consisting of MALT1 and apoptosis inhibitor API2 (Dierlamm et al. 1999). Overexpression of MALT1, or expression of the API2-MALT1 fusion protein, leads to the uncontrolled activation of NF-kappaB which is stimulus-independent. (Zhou et al. 2005)
Mouse anti Human MALT1 recognizes both MALT1 and the MALT1-API2 fusion protein (Murga Penas et al. 2007).
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Carrier Free
- Recombinant protein corresponding to amino acids 701-808 located within the C-terminal of MALT1.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Paraffin 1|
- 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.
References for MALT1 antibody
Ye, H. et al. (2005) MALT lymphoma with t(14;18)(q32;q21)/IGH-MALT1 is characterized by strong cytoplasmic MALT1 and BCL10 expression.
J Pathol. 205 (3): 293-301.
Coornaert, B. et al. (2008) T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20.
Nat Immunol. 9 (3): 263-71.
Rebeaud, F. et al. (2008) The proteolytic activity of the paracaspase MALT1 is key in T cell activation.
Nat Immunol. 9 (3): 272-81.
- Entrez Gene
- GO Terms
- GO:0004197 cysteine-type endopeptidase activity
- GO:0002726 positive regulation of T cell cytokine production
- GO:0005829 cytosol
- GO:0004842 ubiquitin-protein ligase activity
- GO:0004871 signal transducer activity
- GO:0005634 nucleus
- GO:0006508 proteolysis
- GO:0006916 anti-apoptosis
- GO:0007250 activation of NF-kappaB-inducing kinase activity
- View More GO Terms
- GO:0032449 CBM complex
- GO:0032743 positive regulation of interleukin-2 production
- GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade
- GO:0043621 protein self-association
- GO:0048471 perinuclear region of cytoplasm
- GO:0050852 T cell receptor signaling pathway
- GO:0050870 positive regulation of T cell activation
- GO:0051168 nuclear export
- GO:0051259 protein oligomerization
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