LYVE-1 antibody | 4G1

Mouse anti Human LYVE-1

Product Type
Monoclonal Antibody
Clone
4G1
Isotype
IgG2b
Specificity
LYVE-1

Product Code Applications Pack Size List Price Your Price Qty
MCA4629GA
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E WB 0.1 mg loader
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loader
Search for Batch Specific Datasheets

Mouse anti human LYVE-1, clone 4G1 recogniszs human LYVE-1, otherwise known as hyaluronic acid receptor, a type I integral membrane glycoprotein and member of the Link protein superfamily, expressed on the cell surface of both normal and neoplastic lymphatic endothelial cells. LYVE-1 acts a major receptor for the glycosaminoglycan hyaluronan (HA) in both its soluble and immobilized forms.

The binding of LYVE-1 to HA on lymph vessel walls and not to the endothelium of blood vessels, makes LYVE-1 a powerful marker for the identification of lymphatic endothelial cells, and for distinguishing between lymphatic vessels and blood vasculature (Koukourakis et al. 2005).

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G from ascites
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.02% Sodium Azide
10% Glycerol
Immunogen
Recombinant human LYVE-1 (amino acids 25-235) purified from Escherichia coli.
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Fusion Partners
Spleen cells from immunised Balb/c mice were fused with cells of the mouse Sp2/0 myeloma cell line.
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Western Blotting 1/500 1/1000
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Western Blotting
MCA4629GA detects a band of approximately 38 kDa in human A549 (lung carcinoma) cell lysates.

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Description Goat anti Mouse IgG (Fc):FITC
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Description Goat anti Mouse IgG (Fc):HRP
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Description Goat anti Mouse IgG (H/L):HRP (Multi Species Adsorbed)
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Description Goat anti Mouse IgG (H/L):Alk. Phos. (Multi Species Adsorbed)
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Description Goat anti Mouse IgG (H/L):FITC (Multi Species Adsorbed)
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Description Goat anti Mouse IgG (H/L):DyLight®488 (Multi Species Adsorbed)
Goat anti Mouse IgG (H/L):DyLight®680 (Multi Species Adsorbed) STAR117D680GA F WB 0.1 mg loader
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Description Goat anti Mouse IgG (H/L):DyLight®680 (Multi Species Adsorbed)
Goat anti Mouse IgG (H/L):DyLight®800 (Multi Species Adsorbed) STAR117D800GA F IF WB 0.1 mg loader
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Description Goat anti Mouse IgG (H/L):DyLight®800 (Multi Species Adsorbed)
Goat anti Mouse IgG (H/L):DyLight®650 (Multi Species Adsorbed) STAR117D650 F IF 0.1 mg loader
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Description Goat anti Mouse IgG (H/L):DyLight®650 (Multi Species Adsorbed)
Goat anti Mouse IgG (H/L):DyLight®550 (Multi Species Adsorbed) STAR117D550 F IF WB 0.1 mg loader
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Description Goat anti Mouse IgG (H/L):DyLight®550 (Multi Species Adsorbed)

Further Reading

  1. Banerji, S. et al. (1999) LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan.
    J Cell Biol. 144 (4): 789-801.

Synonyms
Hyaluronic Acid Receptor
RRID
AB_2138660
UniProt
Q9Y5Y7
Entrez Gene
LYVE1
GO Terms
GO:0005887 integral to plasma membrane
GO:0005624 membrane fraction
GO:0006810 transport
GO:0006928 cellular component movement
GO:0007160 cell-matrix adhesion
GO:0009653 anatomical structure morphogenesis
GO:0009611 response to wounding
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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