JAB1 antibody | AB08/2G2

Mouse anti JAB1

Product Type
PrecisionAb Monoclonal
Clone
AB08/2G2
Isotype
IgG2b
Format
Purified
Specificity
JAB1

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VMA00414
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Mouse anti Human JAB1 antibody recognizes JAB1, also known as 38 kDa Mov34 homolog, COP9 constitutive photomorphogenic homolog subunit 5, COP9 signalosome complex subunit 5, COPS5, jun activation domain-binding protein 1 or signalosome subunit 5.

The protein encoded by the COPS5 gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be a coactivator that increases the specificity of JUN/AP1 transcription factors (provided by RefSeq, Jul 2008).

Mouse anti Human JAB1 antibody detects a band of 36 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
PrecisionAb Antibodies

Target Species
Human
Western Blotting
Anti JAB1 detects a band of approximately 36 kDa in Jurkat cell lysates.
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Mouse monoclonal antibody purified by affinity chromatography on Protein G from tissue culture supernatant.
Buffer Solution
Phosphate buffered saline.
Preservative Stabilisers
0.09% Sodium Azide (NaN3).
Immunogen
E.coli-derived recombinant human JAB1
Approx. Protein Concentrations
IgG concentration 0.5 mg/ml.
Regulatory
For research purposes only.
Guarantee
12 months from date of despatch.
Acknowledgements
PrecisionAb is a trademark of Bio-Rad Laboratories.

Store undiluted at -20°C, avoiding repeated freeze thaw cycles.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunoprecipitation
Western Blotting 1/1000
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.

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Description Goat anti Mouse IgG (H/L):HRP

UniProt
Q92905
Entrez Gene
COPS5
GO Terms
GO:0005515 protein binding
GO:0000338 protein deneddylation
GO:0003713 transcription coactivator activity
GO:0003743 translation initiation factor activity
GO:0008237 metallopeptidase activity
GO:0046872 metal ion binding
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0006366 transcription from RNA polymerase II promoter
GO:0008180 signalosome
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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