IRF8 antibody | CD01/4H2
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WB ResetMouse anti IRF8
- Product Type
- PrecisionAb Monoclonal
- Clone
- CD01/4H2
- Isotype
- IgG2a
- Format
- Purified
- Specificity
- IRF8
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| Mouse anti IRF8 antibody recognizes interferon regulatory factor 8, also known as ICSBP. IRF8 is an interferon regulatory factor, a group of proteins with essential roles in the innate and adaptive immune system. IRF8 is a transcription factor, and an important regulator of the function of macrophages, B-cells and dendritic cells, and of differentiation of Th9, Th17, and Treg cells (Humblin et al. 2017). IRF8 also facilitates the proliferative burst of natural killer cells during acute viral infection (Adams et al. 2018). IRF8 appears to act as a tumor suppressor in various cancers, including myeloid leukemia (Gaillard et al. 2018) and breast cancers, with IRF8 downregulated in breast cancers and restoration of gene function suppressing cell proliferation and other processes (Luo et al. 2017). |
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- Target Species
- Human
- Western Blotting
- Mouse anti IRF8 antibody detects a band of approximately 50 kDa in Ramos cell lysates
- Product Form
- Purified IgG - Liquid
- Preparation
- Mouse monoclonal antibody affinity purified on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide
- Immunogen
- E. coli-derived recombinant protein of amino acids 1-426 of human IRF8
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- PrecisionAb is a trademark of Bio-Rad Laboratories
Store undiluted at -20°C, avoiding repeated freeze thaw cycles
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1000 |
The PrecisionAb label is reserved for antibodies that meet the defined performance criteria within Bio-Rad's ongoing antibody validation programme. Click here to learn how we validate our PrecisionAb range. Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Further optimization may be required dependent on sample type.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Goat anti Mouse IgG (H/L):HRP | STAR207P | WB | 2 ml |
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| List Price | Your Price | ||||||
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| Description | Goat anti Mouse IgG (H/L):HRP | ||||||
- UniProt
- Q02556
- Entrez Gene
- IRF8
- GO Terms
- GO:0000122 negative regulation of transcription from RNA polymerase II promoter
- GO:0003677 DNA binding
- GO:0003705 sequence-specific enhancer binding RNA polymerase II transcription factor activity
- GO:0005634 nucleus
- GO:0006955 immune response
- GO:0060333 interferon-gamma-mediated signaling pathway
- GO:0060337 type I interferon-mediated signaling pathway
View more products with IRF8 specificity
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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