IL-31 antibody | A12-2F7
Mouse anti Human Interleukin-31:Biotin
- Product Type
- Monoclonal Antibody
- Clone
- A12-2F7
- Isotype
- IgG1
- Specificity
- IL-31
Antibody Quality and Performance Guarantee
| Mouse anti Human interleukin-31 antibody, clone A12-2F7, recognizes interleukin-31 (IL-31), a member of the gp130/IL-6 family of proteins. It is a cytokine that has pro-inflammatory properties. IL-31 is mainly produced by CD4+ T helper and mast cells (Di Salvo et al. 2018). IL-31 acts upon both immune and non-immune cells, regulating signaling of pro-inflammatory cytokines, cell proliferation and tissue remodeling. The effect of IL-31 is mediated by its receptor IL-31RA. Upon binding to this receptor, the JAK/STAT, PI3K/AKT and MAPK pathways can be activated (Zhang et al. 2008). IL-31 has been implicated in chronic inflammation, with elevated levels detected in various skin diseases, Crohn’s disease and ulcerative colitis. Higher IL-31 levels in serum have also been positively correlated with asthma severity (Lai et al. 2016). The biotinylated Mouse anti Human interleukin-31 antibody, clone A12-2F7 (MCA6247B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human interleukin-31 antibody, clone A01-1E4/A09.2-2E6 (MCA6246GA) as the capture antibody. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin - Immunogen
- E. coli derived recombinant human full length interleukin-31 (Ser24-Thr164)
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Cell fusion between immunized BALB/c mouse spleen cells and mouse myeloma SP2/0
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
1.0 ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse anti Human Interleukin-31 | MCA6246GA | E | 0.1 mg |
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| Description | Mouse anti Human Interleukin-31 | ||||||
- UniProt
- Q6EBC2
- Entrez Gene
- IL31
- GO Terms
- GO:0005125 cytokine activity
- GO:0005615 extracellular space
MCA6247B
100005149
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
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