Mouse anti Human insulin-like growth factor 1 antibody, clone 71.1E8 recognizes human IGF-I (Insulin-like Growth Factor I), a 70 amino acid secreted mitogenic polypeptide and member of the insulin gene family, produced primarily by the liver. IGF-I exhibits both autocrine and paracrine properties and has a widespread effect on cells.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Carrier Free
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 18 months from date of despatch.
- Entrez Gene
- GO Terms
insulin receptor binding
insulin-like growth factor receptor binding
cellular component movement
Ras protein signal transduction
muscle organ development
growth factor activity
glycolate metabolic process
positive regulation of gene-specific transcription from RNA polymerase II promoter
positive regulation of phosphatidylinositol 3-kinase cascade
satellite cell maintenance involved in skeletal muscle regeneration
myotube cell development
positive regulation of smooth muscle cell migration
positive regulation of glucose import
insulin-like growth factor binding protein complex
platelet alpha granule lumen
negative regulation of smooth muscle cell apoptosis
bone mineralization involved in bone maturation
regulation of multicellular organism growth
positive regulation of tyrosine phosphorylation of Stat5 protein
positive regulation of insulin-like growth factor receptor signaling pathway
positive regulation of osteoblast differentiation
positive regulation of glycogen biosynthetic process
positive regulation of DNA replication
positive regulation of glycolysis
positive regulation of mitosis
positive regulation of Ras protein signal transduction
positive regulation of fibroblast proliferation
positive regulation of smooth muscle cell proliferation
positive regulation of epithelial cell proliferation
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of IGF-I antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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Secondary Antibodies Available